Blood glucose-lowering effect may be increased by anti-hyperglycaemic drugs, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates, sulfonamide antibiotics. Blood glucose-lowering effect may be reduced by corticosteroids, danazol, diazoxide, diuretics, sympathomimetics (eg, epinephrine, salbutamol, terbutaline); glucagon, INH, phenothiazine derivatives, somatropin, thyroid hormones, estrogens, progestogens (eg, OCs); PIs & atypical antipsychotics (eg, olanzapine & clozapine). Blood glucose-lowering effect may either be potentiated or weakened by β-blockers, clonidine, lithium salts & alcohol. Hypoglycemia then hypergylcemia may occur w/ pentamidine. Reduced or absence of adrenergic counter regulation w/ β-blockers, clonidine, guanethidine & reserpine.