Discontinue use in patients w/ musculoskeletal disorder eg, muscles, back or limb pain. Monitor liver function test in 6- & 12-wk before & after therapy; monitor every 6 mth during therapy. Concomitant use w/ digoxin, warfarin; azole antifungals (eg, ketoconazole, itraconazole), macrolides (eg, erythromycin, clarithromycin), HIV PIs (indinavir, ritonavir, nelfinavir, saquinavir), verapamil, diltiazem, gemfibrozil, nicotinic acid, cyclosporine, amiodarone; colchicines (especially elderly or w/ renal impairment). Patients w/ renal or hepatic impairment, alcoholism, or hypothyroidism. Risk of myopathy & hyperglycemia. Promptly interrupt if serious liver injury w/ clinical manifestations &/or hyperbilirubinemia or jaundice occurs. Measure baseline CK conc before initiation of therapy; routine monitoring for muscle toxicity in childn & adolescents receiving statin therapy. DM; concomitant use w/ drug that may decrease the conc or activity of endogenous steroid hormones eg, spironolactone, & cimetidine. Recent stroke or transient ischemic attack.