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The maximum dose is 40 IU/kg of body weight in all patients, children and adult.
Antirabies serum should be injected as soon as possible after exposure. Infiltrate as much as possible into the depth of the wound and around the wound, although the wound is healed. The remainder of the calculated dose of RIG does not need to be injected IM at a distance from the wound. The injected amount should not exceed the maximum dose. However, if the calculated dose is insufficient for all injuries, sterile saline may be used to dilute 2-3 times to permit thorough infiltration.
In no cases should the dosage of the rabies immunoglobulin be exceeded because immunoglobulins may partially suppress active production of antibodies.
