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Use with extreme caution in subjects with a history of allergic symptoms or hypersensitivity to horse serum. In such cases, the use of human antirabies immunoglobulin is preferable.
Since the antirabies serum is prepared from horse serum. Sensitization to heterologous protein may occur in some individuals. Skin test should be under physician consideration. Skin test performs by injection of 0.02 ml of 1:100 antirabies serum dilution intradermally on the volar surface of the forearm. The result observed 15 minutes later is considered to be positive if 10 mm diameter of wheal appears and the control is negative.
A positive test result should be considered as a warning and human antirabies immunoglobulin should be used in preference. If human antirabies immunoglobulin is not available, equine antirabies serum administration should be under observation by a physician.
A negative test result is not an absolute guarantee for the absence of an immediate allergic type reaction, it should be used with caution. The treating physician should be prepared to manage anaphylaxis. Patient should be observed at least 30 minutes after injection.
Skin test can not predict for delayed hypersensitivity.
In case of doubt, do not hesitate to ask the doctor for advice.
