Local: Burning; itching; irritation; erythema; dryness; folliculitis; hypertrichosis; pruritus; acneiform eruptions; hypopigmentation; perioral dermatitis; allergic contact dermatitis; numbness of fingers; stinging and cracking/tightening of skin; maceration of the skin; secondary infection; skin atrophy; striae; miliaria; telangiectasia. These may occur more frequently with occlusive dressings.
Systemic: Systemic absorption of topical corticosteroids has produced reversible HPA axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glycosuria. This is more likely to occur with occlusive dressings and with the more potent steroids. Patients with liver failure or children may be at a higher risk. Lightheadedness and hives have been reported rarely.
Following prolonged application around the eyes, cataracts and glaucoma may develop. In diffusely atrophied skin, blood vessels may become visible on the skin surface; telangiectasia and purpura may occur at the site of trauma.