Triplixam Contraindications




Full Prescribing Info
Dialysis patients;
Patients with untreated decompensated heart failure;
Severe renal impairment (creatinine clearance below 30 mL/min);
Moderate renal impairment (creatinine clearance below 60 mL/min) for Triplixam doses containing 10mg/2.5mg of perindopril/indapamide combination (i.e., Triplixam 10mg/2.5mg/5mg and 10mg/2.5mg/10mg);
Hypersensitivity to the active substances, to other sulfonamides, to dihydropyridine derivatives, any other ACE-inhibitor or to any of the excipients listed in Description.
History of angioedema (Quincke's oedema) associated with previous ACE inhibitor therapy (see Precautions)
Hereditary/idiopathic angioedemas
Second and third trimesters of pregnancy (see Precautions and Use in Pregnancy & Lactation)
Lactation (see Use in Pregnancy & Lactation)
Hepatic encephalopathySevere hepatic impairment
Severe hypotension
Shock, including cardiogenic shock
Obstruction of the outflow-tract of the left ventricle (e.g. high grade aortic stenosis)
Haemodynamically unstable heart failure after acute myocardial infarction
Concomitant use of Triplixam with aliskiren-containing products in patients with diabetes mellitus or renal impairment (GFR < 60mL/min/1.73m2) (see Interactions and Pharmacology: Pharmacodynamics under Actions)
Concomitant use with sacubitril/valsartan (see Precautions and Interactions).
Extracorporeal treatments leading to contact of blood with negatively charged surfaces (see Interactions),
Significant bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney (see Precautions).
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