Adult Initially 4.6 mg/24 hr. Max dose: 9.5 mg/24 hr. Dose should be increased to 9.5 mg/24 hr after a min of 4 wk treatment. Maintenance dose: 9.5 mg/24 hr.
GI effects. Closely monitor for manifestations of active or occult GI bleeding especially in patients at increased risk (eg, history of ulcer disease, concomitant NSAIDs therapy); loss of appetite or wt loss. Patients w/ sick sinus syndrome or other supraventricular cardiac conduction abnormalities; history of asthma or obstructive pulmonary disease (low wt <50 kg). May cause urinary obstruction. Potential for increased risk of secondary seizures. May exacerbate or induce extrapyramidal symptoms. May cause gradual impairment of ability to drive or operate heavy machinery. Pregnancy & lactation. Childn.
May exaggerate succinylcholine-type muscle relaxation w/ anesth. May interfere activity of anticholinergics. May act synergistically w/ succinylcholine, similar neuromuscular blocking agents or cholinergic agonists eg, bethanechol. Active or occult GI bleeding w/ NSAIDs.
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