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Trulicity

Trulicity

dulaglutide

Manufacturer:

Eli Lilly

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Dulaglutide
Indications/Uses
Type 2 DM as monotherapy in adults inadequately controlled by diet & exercise alone & for whom metformin is inappropriate due to intolerance or CI. Add-on combination therapy w/ glucose-lowering drugs eg, insulin when together w/ diet & exercise is inadequate. Reduce risk of major CV events eg, CV death, non-fatal MI or stroke in adults who have multiple CV risk factors w/ or w/o established CV disease.
Dosage/Direction for Use
SC Monotherapy 0.75 mg once wkly. Add-on therapy 1.5 mg once wkly. Potentially vulnerable population Initially 0.75 mg once wkly.
Administration
May be taken with or without food.
Contraindications
Special Precautions
Not to be administered IV or IM. Not to be used in patients w/ type 1 DM or for treatment of diabetic ketoacidosis. Discontinue use if acute pancreatitis occurs. Not recommended for patients w/ severe GI disease including severe gastroparesis. Increased risk of hypoglycaemia. CHF. May cause deterioration of renal function including acute renal failure in patients w/ impaired renal function. Monitor patients w/ history of diabetic retinopathy for progression. May affect ability to drive or use machines. Not recommended in patients w/ end-stage renal disease (<15 mL/min/1.73 m2). Not recommended during pregnancy. Not to be used during lactation. Childn <18 yr.
Adverse Reactions
Hypoglycaemia; nausea, diarrhoea, vomiting, abdominal pain. Decreased appetite, dyspepsia, constipation, flatulence, abdominal distention, GERD, eructation; fatigue; sinus tachycardia, 1st degree AV block.
Drug Interactions
Delayed gastric emptying & affected absorption rate w/ drugs requiring rapid GI absorption. Increased exposure, Cmax & tmax w/ sitagliptin.
MIMS Class
Antidiabetic Agents
ATC Classification
A10BJ05 - dulaglutide ; Belongs to the class of glucagon-like peptide-1 (GLP-1) analogues. Used in the treatment of diabetes.
Presentation/Packing
Form
Trulicity soln for inj 0.75 mg/0.5 mL
Packing/Price
4's
Form
Trulicity soln for inj 1.5 mg/0.5 mL
Packing/Price
4's
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