Hypersensitivity to the active substances or to any of the excipients listed in Description.
Severe reaction to a previous dose of the combination vaccine or any of its constituents is an absolute contraindication to subsequent doses of the combination vaccine or the specific vaccine known to have provoked an adverse reaction.
Convulsions/seizures or abnormal cerebral signs in the newborn period or other serious neurological abnormalities are contraindications to the pertussis component. In these cases, the vaccine should not be given as a combination vaccine but DT should be given instead of DTwP and Hep B and Hib vaccine given separately. The vaccine will not harm individuals currently or previously infected with the hepatitis B virus.