Verorab

Verorab

vaccine, rabies

Manufacturer:

Sanofi Pasteur

Distributor:

Zuellig Pharma
Concise Prescribing Info
Contents
Inactivated purified rabies vaccine produced in Vero cells
Indications/Uses
Pre- & post-exposure prevention against rabies in childn & adults.
Dosage/Direction for Use
Administer 1 dose (0.5 mL) by IM into the anterolateral region of the thigh muscle until infant 12 mth & into the deltoid muscle after infant 12 mth. Intradermal may be used as an alternative on upper or forearm; 1 intradermal dose is 0.1 mL of reconstituted vaccine. Pre-exposure 3 doses (0.5 mL) on D0, D7, & D28 or D21 for primary vaccination, followed by booster doses depending on the nature of risk. Intradermal 0.1 mL on D0, D7 & D21 or D28. Post-exposure Non-immunised (did not receive pre-exposure vaccination) Administer 5 doses (0.5 mL) at D0, D3, D7, D14 & D28. Intradermal Original Thai Red Cross regimen: 1 inj of 0.1 mL at different sites on D0, D3, D7 & 1 inj at 1 site on D28 (or D30) & D90. Updated Thai Red Cross regimen: 1 inj of 0.1 mL at 2 sites on D0, D3, D7 & D28. Fully immunised 2 booster doses at D0 & D3, if pre-exposure vaccination was performed <5 yr before. Intradermal 2 inj on D0, D3.
Contraindications
Hypersensitivity. Fever or acute disease.
Special Precautions
Do not inj intravascularly & in the buttocks region. Hypersensitivity to polymyxin, streptomycin, or neomycin. Regularly perform serological tests. Perform serological test 2-4 wk after vaccination in immunodeficient patients. Thrombocytopenia or clotting disorders. May temporarily affect ability to drive or use machines.
Adverse Reactions
Adenopathy, lymphadenopathy; allergic skin reaction eg, urticarial, pruritus, oedema; allergic reaction w/ resp disorders (dyspnea, angioedema); anaphylactic reaction, serum sickness-like reaction; headache (cephalalgia), dizziness, somnolence; abdominal pain, nausea, diarrhoea, vomiting; myalgia, arthralgia; inj site pain, erythema & induration, haematoma, oedema & pruritus; hyperthermia, shivering, malaise, flu-like syndrome; convulsions, encephalopathy; asthenia. Resp pauses 2-3 days after vaccination in premature infants.
Drug Interactions
Corticosteroids & immunosuppressive treatments may interfere w/ Ab production.
ATC Classification
J07BG01 - rabies, inactivated, whole virus ; Belongs to the class of rabies viral vaccines.
Presentation/Packing
Form
Verorab vaccine 1 dose
Packing/Price
(+ syringe diluent 0.5 mL) 1's
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