Increased insulin requirements w/ corticosteroids, INH, certain lipid-lowering drugs (eg, niacin), estrogens, OCs, phenothiazines & thyroid replacement therapy. Decreased insulin requirements w/ oral hypoglycemic agents, salicylates, sulfa antibiotics, certain antidepressants (MAOIs), certain ACE-inhibitors, β-adrenergic blockers, inhibitors of pancreatic function (eg, octreotide), & alcohol. β-adrenergic blockers.