Treatment of Chronic Hepatitis B: The recommended dose when used as a monotherapy or in combination with interferon (at the labeled dose and schedule for interferon) is 1.6 mg (900 mcg/m2) administered SC twice a week with doses separated by 3 or 4 days. Therapy should be continued for 6 months (52 doses) without interruption. Patients weighing <40 kg should receive a Zadaxin dose of 40 mcg/kg.
Vaccine Adjuvant: The recommended dose when used as an enhancement to viral vaccines is 900 mcg/m2 (1.6 mg) administered SC twice a week with doses separated by 3 or 4 days and the 1st dose given coincident with the vaccine. Therapy should be continued for 4 weeks (a total of 8 doses) after a single-dose vaccine immunization regimen. For a multi-dose vaccine immunization regimen, therapy should continue twice a week between vaccinations and for 3 weeks (a total of 5-6 doses) after the last vaccination.
Zadaxin should not be given IM or IV. It should be reconstituted with 1 mL of the diluent provided immediately prior to use. It should be used immediately after reconstitution. At the discretion of the physician, the patient may be taught to self-administer the medication.