Zinnat Special Precautions





Zuellig Pharma
Full Prescribing Info
Special Precautions
Special care is indicated in patients who have experienced an allergic reaction to penicillin or other β-lactams.
As with other antibiotics, use of Zinnat may result in the overgrowth of Candida. Prolonged use may also result in the overgrowth of nonsusceptible organisms (eg, Enterococci, Clostridium difficile), which may require interruption of treatment.
Pseudomembranous colitis has been reported with the use of broad-spectrum antibiotics, therefore, it is important to consider its diagnosis in patients who develop serious diarrhoea during or after antibiotic use.
The Jarisch-Herxheimer reaction has been seen following Zinnat treatment of Lyme disease. It results directly from the bactericidal activity of Zinnat on the causative organism of Lyme disease, the spirochaete Borrelia burgdorferi. Patients should be reassured that this is a common and usually self-limiting consequence of antibiotic treatment of Lyme disease.
The sucrose content of Zinnat suspension and granules should be taken into account when treating diabetic patients, and appropriate advice provided.
Zinnat suspension contains aspartame, which is a source of phenylalanine, and so should be used with caution in patients with phenylketonuria.
With a sequential therapy regimen, the timing of change to oral therapy is determined by severity of the infection, clinical status of the patient and susceptibility of the pathogens involved. If there is no clinical improvement within 72 hrs, then the parenteral course of treatment must be continued.
Refer to the relevant prescribing information for cefuroxime sodium before initiating sequential therapy.
Effects on the Ability to Drive or Operate Machinery: As Zinnat may cause dizziness, patients should be warned to be cautious when driving or operating machinery.
Use in pregnancy & lactation: There is no experimental evidence of embryopathic or teratogenic effects attributable to Zinnat but, as with all drugs, it should be administered with caution during the early months of pregnancy.
Cefuroxime is excreted in human milk, and consequently caution should be exercised when Zinnat is administered to a nursing mother.
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