The usual course of therapy is 7 days (range 5-10 days).
For optimal absorption, cefuroxime axetil should be taken with food.Adults: Most Infections:
250 mg twice daily.Urinary Tract Infections:
125 mg twice daily.Mild to Moderate Lower Respiratory Tract Infections (eg, Bronchitis):
250 mg twice daily.More Severe Lower Respiratory Tract Infections, or if Pneumonia is Suspected:
500 mg twice daily.Pyelonephritis:
250 mg twice daily.Uncomplicated Gonorrhoea:
Single dose of 1 g.Lyme Disease: Adults and Children >12 years:
500 mg twice daily for 20 days.
Sequential Therapy: Pneumonia:
1.5 g Zinacef (cefuroxime sodium) 3 or 2 times daily (IV or IM) for 48-72 hrs, followed by 500 mg twice daily Zinnat (cefuroxime axetil) oral therapy for 7-10 days.Acute Exacerbations of Chronic Bronchitis:
750 mg Zinacef (cefuroxime sodium) 3 or 2 times daily (IV or IM) for 48-72 hrs, followed by 500 mg twice daily Zinnat (cefuroxime axetil) oral therapy for 5-10 days.
Duration of both parenteral and oral therapy is determined by the severity of the infection and the clinical status of the patient.Children: Most Infections:
Recommended Dose: 10 mg/kg twice daily up to maximum dose of 250 mg/day. In children ≥2 years with otitis media or where appropriate, with more severe infections, the dose is 250 mg twice daily or 15 mg/kg twice daily, up to a maximum dose of 500 mg/day.
Zinnat tablets should not be crushed and are therefore unsuitable for treatment of patients eg, younger children, who cannot swallow tablets. In children, Zinnat oral suspension may be used.
There is no clinical trial data available on the use of Zinnat in children <3 months.
In infants and children, it may be preferable to adjust dosage according to weight or age. The dose in infants and children 3 months to 12 years is 10 mg/kg twice daily for most infections, to a maximum of 250 mg daily. In otitis media or more severe infections, the recommended dose is 15 mg/kg twice daily to a maximum of 500 mg daily.
Tables 1 and 2, divided by age group and weight, serve as a guideline for simplified administration from measuring spoons (5 mL).
10 mg/kg Dosage for Most Infections: See Table 1.Click on icon to see table/diagram/image
15 mg/kg Dosage for Otitis Media and More Serious Infections: See Table 2.Click on icon to see table/diagram/image
Cefuroxime is also available as the sodium salt (Zinacef) for parenteral administration. This permits parenteral therapy with Zinnat to be followed by oral therapy in situations where a change from parenteral to oral treatment is clinically indicated.Administration:
Suspension: Always shake the bottle vigorously before taking the medication.
The reconstituted suspension when refrigerated between 2 and 8°C can be kept for up to 10 days.
If desired, Zinnat suspension can be further diluted from multidose bottles in cold fruit juices or milk drinks and should be taken immediately.
The reconstituted suspension or granules should not be mixed with hot liquids.
Directions for Reconstituting Suspension in Multidose Bottles: Shake the bottle to loosen the granules. Remove the cap and the heat seal membrane. If the latter is damaged or not present, the product should be returned to the pharmacist.
Add the total amount of water to the bottle as stated on its label. Replace the cap.
Invert the bottle and rock vigorously (for at least 15 sec).
Turn the bottle into an upright position and shake vigorously.
If using a dosing syringe, allow the reconstituted suspension to stand for at least 1 hr before taking the first dose.