May induce GI ulceration in patient with history of GI disease especially patient who take celecoxib with aspirin.
Complication may occur with GI tract e.g. bleeding, perforation; may be fatal, in rare cases.
Celecoxib is not a substitute for aspirin for cardiovascular prophylaxis.
Increase of severe adverse reaction of celecoxib in cardiovascular especially myocardial infarction has been reported in long term study in treatment of sporadic adenomatous polyps compare between celecoxib 200 mg two times daily and placebo, celecoxib 400 mg two times daily and placebo.
The risk of cardiovascular adverse effect tends to be higher depending on the dose and treatment time, therefore celecoxib should be use of minimum dose and short term treatment.
Use with caution in patients with hepatic impairment, cardiac disease, hypertension because fluid retention may occur.
Erythema multiforme, exfoliative dermatitis and Steven-Johnson Syndrome can occur in some patients.