Prostate cancer suitable for hormonal manipulation, breast cancer in pre- & peri-menopausal women suitable for hormonal manipulation, endometriosis, endometrial thinning, uterine fibroids, assisted reproduction.
1 depot SC into the anterior abdominal wall, every 28 days. Endometrial thinning 2 inj to be given 4 wk apart. Surgery w/in 2 wk after 2nd inj. Uterine fibroids 3.6 mg w/ supplementary Fe for up to 3 mth before surgery.
Hypersensitivity reactions (rare), arthralgia, nonspecific paraesthesias, rash, BP changes. Male Hot flushes, sweating, decrease in potency. Infrequently breast swelling & tenderness. Temporary increase in bone pain. Isolated cases of ureteric obstruction & spinal cord compression recorded. Female Hot flushes, sweating, change in libido, headache, mood changes including depression, vag dryness, change in breast size. Temporary increase in signs & symptoms. Rarely, patients w/ bony metastases have developed hypercalcaemia on initiation of therapy.
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