Zomoxin Eye Drops

Zomoxin Eye Drops Mechanism of Action





Prosp Pharma
Full Prescribing Info
Pharmacology: Pharmacodynamics: Moxifloxacin is a fluoroquinolone anti-infective agent. Moxifloxacin inhibits DNA synthesis in susceptible organism via inhibition of topoisomerases II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of DNA. Moreover, Topoisomerase IV is an enzyme to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Pharmacokinetics: For topical application of moxifloxacin 0.5% ophthalmic solutions to the eye, the drug is absorbed systematically and low moxifloxacin concentration are attained in plasma.
In a study in healthy adult who received bilateral topical ocular doses of moxifloxacin 0.5% ophthalmic solutions 3 times a day. The mean steady-state Cmax and estimated daily exposure AUC values were 1,600 and 1,000 times lower than the mean Cmax and AUC reported after therapeutic 400 mg doses of moxifloxacin. The plasma half-life of moxifloxacin was estimated to be 13 hours.
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