Korea United Pharm


S Charoen Bhaesaj Trading
Concise Prescribing Info
HSV infections. Varicella zoster virus infections. Neonatal HSV infections.
Dosage/Direction for Use
Slow IV infusion Given at a constant rate over at least 1 hr. HSV infections: Mucocutaneous HSV infections Adult & childn ≥12 yr 5 mg/kg every 8 hr for 7-14 days, childn <12 yr 10 mg/kg every 8 hr for 7-14 days; severe initial genital herpes Adult & childn ≥12 yr 5 mg/kg every 8 hr for 5-7 days; HSV encephalitis Adult & childn ≥12 yr 10 mg/kg every 8 hr for 10 days, 3 mth to <12 yr 20 mg/kg every 8 hr for 10 days. Varicella zoster virus infections (immunocompromised patients) Adult & childn ≥12 yr 10 mg/kg every 8 hr for 7 days, childn <12 yr 20 mg/kg every 8 hr for 7 days. Neonatal HSV infections Infant from birth to 3 mth 10 mg/kg every 8 hr for 10 days. Dosage adjustments: Impaired renal function CrCl >50 mL/min Recommended dose: Every 8 hr, CrCl 25-50 mL/min Recommended dose: Every 12 hr, CrCl 10-25 mL/min Recommended dose: Every 24 hr, CrCl 0-10 mL/min, patient receiving continuous ambulatory peritoneal dialysis (CAPD) Half of the usual recommended dose administered every 24 hr; patient receiving hemodialysis Half of the usual recommended dose administered every 24 hr after dialysis.
Hypersensitivity to aciclovir or valaciclovir.
Special Precautions
Maintain adequate hydration during therapy. Signs & symptoms of encephalopathy. Patient w/ underlying neurologic abnormalities & w/ serious renal, hepatic, or electrolyte abnormalities or substantial hypoxia. Concomitant use w/ other nephrotoxic drugs. Renal abnormal function & hepatic dysfunction. Pregnancy & lactation. Childn. Elderly.
Adverse Reactions
Severe local inflammatory reactions, including tissue necrosis; renal impairment; reversible neurological reactions eg, confusion, hallucinations, agitation, tremors, somnolence, psychosis, paresthesia, dizziness, headache, fatigue, convulsions & coma; diarrhea, vomiting, nausea, abdominal pain; anemia, thrombocytopenia, lymphadenopathy, leukopenia, disseminated intravascular coagulation, hemolysis, leukocytoclastic vasculitis; alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria; fever, pain.
Drug Interactions
May cause toxicosis of theophylline. May have increased level w/ foscarnet, mycophenolate, & tenofovir. May increase level of clozapine, mycophenolate, tenofovir, tizanidine, & zidovudine. Neurotoxicity w/ zidovudine. Increased mean t½ & area under the concentration-time curve w/ probenecid. Additive or synergistic antiviral effect w/ interferon.
MIMS Class
ATC Classification
J05AB01 - aciclovir ; Belongs to the class of nucleosides and nucleotides excluding reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
Zoylex soln for infusion 250 mg/10 mL
10 × 1's
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