Local effects: Severe local inflammatory reactions, including tissue necrosis, have occurred following infusion of aciclovir into extravascular tissues.
Renal effects: Elevation of BUN and serum creatinine level, anuria, red blood cell in urine precipitation have been reported occasionally. Renal impairment developing during treatment with aciclovir have been reported most frequently when the drug was administered by rapid (over less than 10 minutes) IV infusion rather than over the recommended period for IV infusion (at least 1 hour).
Psychoneurotic effects: Reversible neurological reactions such as confusion, hallucinations, agitation, tremors, somnolence, psychosis, paresthesia, dizziness, headache, fatigue, convulsions and coma have been associated with I.V. therapy, usually in medically complicated cases.
GI effects: Usually diarrhea, vomiting, nausea, and abdominal pain have been reported in patients receiving aciclovir.
Hematologic: Usually occurred anemia, thrombocytopenia, lymphadenopathy, leukopenia, disseminated intravascular coagulation, hemolysis, leukocytoclastic vasculitis.
Skin: Alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria.
Other Adverse Effects: Fever and pain have been reported in patients receiving aciclovir. Elevated liver function test results, hepatitis, hyperbilirubinemia, jaundice, hypotension, myalgia, peripheral edema, thirst, and visual abnormalities have been reported rarely in patients receiving aciclovir