Zoylex

Zoylex Dosage/Direction for Use

aciclovir

Manufacturer:

Korea United Pharm

Distributor:

S Charoen Bhaesaj Trading
Full Prescribing Info
Dosage/Direction for Use
Recommended Dose: Aciclovir should be given by slow IV infusion at a constant rate over at least 1 hour. (See Table 1.)

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Dosage in patients with impaired renal function. The following adjustments in dosage are suggested. (See Table 2.)

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Use in geriatric: This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
Mode of Administration: Aciclovir should be given by slow IV infusion at a constant rate over at least 1 hour.
Aciclovir may given by infusion using a controlled-rate infusion pump.
Aciclovir should not be diluted to a concentration greater than 5 mg/ml (0.5%w/v) for administration by infusion.
When diluted in accordance with the recommended schedules, aciclovir is known to be compatible with the following infusion fluids and stable for up to 12 hours at temperature between 15 to 25°C: Sodium chloride intravenous infusion (0.45% and 0.9%w/v); Sodium chloride (0.18%w/v) and Glucose (4%w/v) intravenous infusion; Sodium chloride (0.45%w/v) and Glucose (2.5%w/v) intravenous infusion; Compound sodium lactate intravenous infusion (Hartmann's solution).
After addition of aciclovir to an infusion solution the mixture should be shaken to ensure thorough mixing.
Since no antimicrobial preservative is included, dilution must be carried out under full aseptic condition, immediately before use, and any unused solution discard.
When visible turbidity or crystallization appears in the solution before or during the infusion, the preparation should be discarded. The diluted solutions should not be refrigerated.
ZOYLEX is alkaline solution. It is incompatible with other drug according to change of pH. Therefore, combination of aciclovir and other drug should be avoided.
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