Care should be observed when administering aciclovir injection to patients with renal abnormal function, patients with hepatic dysfunction, children patient, and elderly patients.
Aciclovir should be used with caution in patients receiving other nephrotoxic drugs concurrently since the risk of aciclovir-induced renal impairment.
Adequate hydration should be maintained in patients receiving aciclovir.
Acivlovir should be given only by slow IV infusion over a period of at least 1 hour to reduce the risk of aciclovir-induced renal impairment.
Parenteral aciclovir therapy can cause signs and symptoms of encephalopathy. Aciclovir should be used with caution in patient with underlying neurologic abnormalities and in patients with serious renal, hepatic, or electrolyte abnormalities or substantial hypoxia.