Hypertension
Adult: 200 mg/day in divided doses, increased wkly according to patient response.
Oral
Angina pectoris, Cardiac arrhythmias
Adult: 200-400 mg/day in divided doses.
Chỉ định và Liều dùng
Oral
Hypertension Adult: 200 mg/day in divided doses, increased wkly according to patient response. Oral Angina pectoris, Cardiac arrhythmias Adult: 200-400 mg/day in divided doses.
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Chống chỉ định
2nd and 3rd degree AV block; sinus bradycardia; uncontrolled heart failure; asthma or bronchospasm, severe peripheral arterial disease, metabolic acidosis, phaeochromocytoma. Concomitant use w/ clonidine.
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Thận trọng
1st degree AV block. May mask symptoms of hyperthyroidism and hypoglycaemia. May unmask myasthenia gravis. May aggravate psoriasis. Abrupt withdrawal may cause angina, MI, ventricular arrhythmias and death. Patients on long-term treatment should discontinue medication gradually over 1-2 wk. Pregnancy and lactation.
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Phản ứng phụ
Bradycardia; heart failure, heart block; hypotension; bronchospasm; fatigue; coldness of extremities; pneumonitis; pulmonary and retroperitoneal fibrosis; pleurisy; CNS effects; myopathies; GI disturbances; reversible alopoecia; skin rash; pruritus; lupus-like syndrome; male impotence; sclerosing peritonitis; muscle cramps; paraesthesias; peripheral neuropathy; haematological reactions. Changes in blood concentrations of glucose, triglycerides and cholesterol.
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Tương tác
Concomitant use w/ other drugs that cause hypotension; NSAIDs; other cardiac depressants; sotalol; digoxin; insulin and oral hypoglycaemics; sympathomimetics; ACE inhibitors; Ca-channel blockers, verapamil. Anaesthetics causing myocardial depression (e.g. ether, cyclopropane, trichloroethylene).
Potentially Fatal: Increased risk of withdrawal HTN w/ clonidine. Withdraw several days before slowly discontinuing clonidine. |
Tác dụng
Description: Alprenol is a non-cardioselective β-blocker w/ intrinsic sympathomimetic activity and some membrane-stabilising properties.
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Phân loại MIMS
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References
Buckingham R (ed). Alprenolol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 25/11/2013.
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