Aluminium hydroxide + Magnesium hydroxide


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Gastrointestinal hyperacidity
Adult: Available preparations:
Aluminium hydroxide 200 mg and magnesium hydroxide 200 mg per 5 mL susp
Aluminium hydroxide 220 mg and magnesium hydroxide 195 mg per 5 mL susp
Aluminium hydroxide 175 mg and magnesium hydroxide 200 mg per 5 mL susp
10-20 mL 4 times daily, given 20 minutes to 1 hour after meals and at bedtime or as required. Max: 80 mL per 24 hours.

Aluminium hydroxide 160 mg and magnesium hydroxide 105 mg chewable tablet
Chew 2-4 tab 4 times a day or as required. Max: 16 tab per 24 hours.
Child: ≥12 years Same as adult dose.
Chống chỉ định
Severe abdominal pain and/or possibility of bowel obstruction. Severely debilitated patients. Renal failure.
Thận trọng
Patient with porphyria (and undergoing haemodialysis), diarrhoea or constipation. Renal impairment. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Hypophosphataemia (prolonged use), diarrhoea or constipation.
Gastrointestinal disorders: Abdominal pain.
Injury, poisoning and procedural complications: Hyperaluminaemia.
Metabolism and nutrition disorders: Hypermagnesaemia (prolonged use).
Quá liều
Symptoms: Abdominal pain, diarrhoea, vomiting. Large doses may aggravate intestinal obstruction and ileus in patients at risk. Management: Correct fluid deficiency if necessary. Acute overdose may be treated by administration of calcium gluconate IV, rehydration, and forced diuresis.
Tương tác
Interferes with the absorption of ciprofloxacin, chloroquine, hydroxychloroquine, chlorpromazine, cefdinir, cefpodoxime, ketoconazole, levothyroxine, rifampicin, rosuvastatin, tetracyclines, vitamins. May reduce the effect of polystyrene sulphonate. Decreased serum concentration of velpatasvir. Increased absorption with citrate-containing preparations. May decrease absorption of Fe salts.
Magnesium hydroxide: Increases the excretion of salicylates.
Tác dụng
Description: Aluminium hydroxide is a slow-acting antacid that binds phosphate in the gastrointestinal tract to form insoluble complexes and reduces phosphate absorption. It also acts as an astringent and may cause diarrhoea.
Magnesium hydroxide is a fast-acting antacid which counteracts the constipating effect of aluminium hydroxide.
Pharmacokinetics:
Metabolism: Aluminium hydroxide: Slowly converted to aluminium chloride in the stomach.
Excretion: Via urine.
Đặc tính

Chemical Structure Image
Aluminium hydroxide

Source: National Center for Biotechnology Information. PubChem Database. Aluminum hydroxide, CID=10176082, https://pubchem.ncbi.nlm.nih.gov/compound/Aluminum-hydroxide (accessed on Jan. 20, 2020)


Chemical Structure Image
Magnesium hydroxide

Source: National Center for Biotechnology Information. PubChem Database. Milk of magnesia, CID=73981, https://pubchem.ncbi.nlm.nih.gov/compound/Milk-of-magnesia (accessed on Jan. 20, 2020)

Bảo quản
Store between 20-25°C.
Phân loại MIMS
Thuốc kháng acid, chống trào ngược & chống loét
Tài liệu tham khảo
Anon. Aluminium Hydroxide and Magnesium Hydroxide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/02/2018 .

Buckingham R (ed). Aluminium Hydroxide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/02/2018.

ConRx-AR Tablet, Chewable (Eagle Distributors, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/02/2018 .

Mag-Al Liquid (Pharmaceutical Associates, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 05/02/2018 .

Superdrug Indigestion Relief Liquid (Chemidex Pharma Limited). MHRA. https://products.mhra.gov.uk/. Accessed 05/02/2018 .

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