Ampicillin + Flucloxacillin


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Severe infections
Adult: Each cap contains ampicillin 250 mg and flucloxacillin 250 mg: >10 yr 1 cap 4 times/day. Each 5 mL susp contains ampicillin 125 mg and flucloxacillin 125 mg: >10 yr 10 mL 4 times/day.
Child: Each 5 mL susp contains ampicillin 125 mg and flucloxacillin 125 mg: ≤10 yr 5 mL 4 times/day.

Parenteral
Severe infections
Adult: IM/IV: Each 500 mg vial contains ampicillin 250 mg and flucloxacillin 250 mg: >10 yr 500 mg 4 times/day.
Child: IM/IV: Each 500 mg vial contains ampicillin 250 mg and flucloxacillin 250 mg: <2 yr 125 mg 4 times/day; 2-10 yr 250 mg 4 times/day.
Cách dùng
Should be taken on an empty stomach. Take 30 min-1 hr before meals.
Hướng dẫn pha thuốc
Parenteral:
IM: Add 1.5 mL water for inj to the vial. IV: Dissolve 500 mg in 10 mL water for inj. Administer by slow IV inj.
Tương kỵ
Incompatible w/ aminoglycosides. IV should not be mixed w/ other proteinaceous fluids (e.g. protein hydrolysates), IV lipid emulsions or w/ blood products.
Chống chỉ định
Hypersensitivity to β-lactam antibiotics (e.g. cephalosporins, penicillins). Patient w/ history of flucloxacillin-associated jaundice/hepatic dysfunction; infectious mononucleosis; acute or chronic leukaemia.
Thận trọng
Renal and hepatic impairment. Pregnancy and lactation.
Phản ứng phụ
Hypersensitivity reactions (e.g. rash, erythema multiforme, purpura, eosinophilia, angioneurotic oedema, fever, arthralgia, myalgia); GI disturbances, pseudomembranous colitis; hepatitis, cholestatic jaundice, transient elevation of liver enzymes; interstitial nephritis; leucopenia, thrombocytopenia.
Potentially Fatal: Anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis.
MonitoringParameters
Monitor renal and hepatic function esp during prolonged use.
Quá liều
Symptoms: GI effects (e.g. nausea, vomiting and diarrhoea). Management: Symptomatic and supportive treatment. Ampicillin may be removed via haemodialysis.
Tương tác
May reduce efficacy of oral contraceptives. Increased and prolonged serum levels of both ampicillin and flucloxacillin w/ probenecid. Increased risk of allergic skin reactions w/ allopurinol.
Lab Interference
May cause false-positive result in glucose testing.
Tác dụng
Description: Ampicillin exerts bactericidal action on both gm+ve and gm-ve organisms. Its spectrum includes gm+ve organisms e.g. Strep. pneumoniae and other Streptococci, L. monocytogenes and gm-ve bacteria e.g. M. catarrhalis, N. gonorrhoea, N. meningitidis, E. coli, P. mirabilis, Salmonella, Shigella, and H. influenzae. Ampicillin exerts its action by inhibiting the synthesis of bacterial cell wall. Flucloxacillin is bactericidal against penicillinase-producing and non-penicillinase-producing staphylococci. Its activity against streptococci e.g. Strep. pneumoniae and Strep. pyogenes is less than that of benzylpenicillin, but sufficient to be useful when these organisms are present w/ penicillin-resistant staphylococci.
Pharmacokinetics:
Absorption: Both are well absorbed from the GI tract and absorption is reduced by food. Peak plasma concentration: Ampicillin: Approx 1-2 hr; Flucloxacillin: Approx 1 hr.
Distribution: Both cross the placenta and small amounts are distributed into breast milk. Plasma protein binding: Ampicillin: Approx 20%; Flucloxacillin: Approx 95%.
Metabolism: Ampicillin: Metabolised to some extent to penicilloic acid.
Excretion: Ampicillin: Via urine approx 20-40% as unchanged drug (oral), 60-80% (parenteral); via bile and milk (in small amount). Flucloxacillin: Via urine approx 66% (oral), approx 76% (parenteral). Plasma half-life: Ampicillin: Approx 1-1.5 hr; Flucloxacillin: Approx 1 hr.
Bảo quản
Store below 25°C. Reconstituted susp: Store at 2-8°C.
Phân loại MIMS
References
Anon. Ampicillin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/09/2013.

Buckingham R (ed). Ampicillin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/09/2013.

Buckingham R (ed). Flucloxacillin. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/09/2013.

Co-fluampicil Capsules (Crescent Pharma Limited). MHRA. https://products.mhra.gov.uk/. Accessed 06/09/2013.

Co-Fluampicil Oral Suspension 125/125mg/5ml (Crescent Pharma Limited). MHRA. https://products.mhra.gov.uk/. Accessed 06/09/2013.

McEvoy GK, Snow EK, Miller J et al (eds). Ampicillin, Ampicillin Sodium, Ampicillin Trihydrate. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 06/09/2013.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Ampicillin + Flucloxacillin từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2021 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in