Anaferon for children

Anaferon for children

interferon gamma

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Materia Medica
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Contents
Affinity-purified antibodies to human interferon gamma.
Description
Each orodispersible tablet contains: Active ingredient: Affinity purified antibodies to human gamma interferon 3 mg*.
*water-ethanol mixture of active substance dilutions with concentration not more than 10-16 ng/g used for saturation of lactose.
Excipients/Inactive Ingredients: lactose, microcrystalline cellulose, magnesium stearate.
Action
Pharmacotherapeutic Group: Immunomodulators, Antivirals. ATC Codes: L03, J05AX.
Pharmacology: Pharmacodynamics: When used for prevention and treatment, drugs that act immunomodulatory and antiviral. The effect is determined experimentally and clinically for influenza virus (bird flu including), parainfluenza virus, herpes simplex type 1 and type 2 (herpes lips, genital herpes), the virus that causes herpes (chickenpox, mononucleosis increasing evidence of infection) viral encephalitis transmitted from ticks (tick-borne encephalitis virus), rotavirus, coronavirus, calicivirus, adenoviruses, respiratory syncytial virus. The drug reduces the penetration of the virus in tissues, the impact on the system's endogenous interferon and related cytokines, which reduces the production of interferons "soon" (IFNa/β) and interferon gamma (IFNγ).
The drug stimulates immune response, humoral and cell mediated. Anaferon for children increases the production of antibodies (including exocrine IgA), activating the function of T-effectors and T-helpers (Th) and regulates the ratio between these factors. Enhancing drugs affect the function of Th reserves and other cells involved in immune response.
Drugs generate an immune response of both Th1 and fontanelle coordinates through enhanced Th2 produces THL (IFNγ, IL-2) and Th2 (IL-4, 10) cytokines, conditioned activity balance THL/Th2. Drugs that enhance the activity of macrophages and natural killer cells (NK cells). It also is against the nature of the mutation.
Pharmacokinetics: The sensitivity of the current chemical and physical methods (gas-liquid chromatography, high-performance liquid chromatography with mass spectrometry mounted) not yet determined the amount of antibodies at very low levels in the translation biology, tissue and organs, so, with the current technical conditions unidentified pharmacokinetic properties of Anaferon for children.
Indications/Uses
Prophylaxis and treatment of acute viral respiratory infections (including influenza). Complex therapy of infections caused by herpes viruses (infectious mononucleosis, varicella, labial herpes, genital herpes).
Complex therapy and prophylaxis of relapses of chronic herpes virus infection including labial and genital herpes.
Complex therapy and prophylaxis of other acute and chronic viral infections caused by tick-borne encephalitis virus, enterovirus, rotavirus, coronavirus, calicivirus.
Used in a complex therapy of bacterial infections.
Complex therapy of secondary immunodeficiencies of various etiology including prophylaxis and treatment of complications of virus and bacterial infections.
Dosage/Direction for Use
Oral route.
Anaferon for children should be administered to children beginning from the age of 1 month.
One tablet per intake (the tablet should be held in the mouth until it is completely dissolved, not during the meal).
When indicated to younger children (1 month - 3 years old) the tablet is recommended to be dissolved in a small volume (a tablespoonful) of drinking water at room temperature.
URI's, influenza, intestinal infections, herpes virus infections, neuroinfections: Treatment should begin as early as possible - beginning from the first onset of symptoms of an acute viral infection according to the following regimen: 1 tablet is taken every 30 minutes during the first 2 hours, then 3 more tablets should be administered in equal time intervals during the first day of treatment. Beginning from the second day of treatment 1 tablet is administered 3 times a day until full recovery.
If no improvement occurs by the third day of treatment of acute respiratory virus infections and influenza, a doctor should be consulted.
Throughout the epidemic season for prophylaxis purposes the drug is administered 1 tablet daily for 1-3 months.
Genital herpes: In cases of acute manifestations of genital herpes the drug is taken in equal time intervals according to the following regimen: 1-3 days - 1 tablet is taken 8 times/day, furthermore 1 tablet is taken 4 times/day for not less than 3 weeks.
For the prophylaxis of relapses of chronic herpes virus infections - 1 tablet is taken daily. The recommended duration of the prophylactic course should be defined individually and may reach 6 months.
When administering the drug for treatment and prophylaxis of immunodeficiencies, in the complex therapy of bacterial infections - 1 tablet is administered daily.
If necessary Anaferon for children can be co-administered with other antiviral and symptomatic drugs.
Anaferon for children is not recommended for use in children below age of 1 month due to a lack of data on safety and efficacy.
Overdosage
No cases of overdose have been reported.
Dyspepsia caused by excipients is possible in accidental overdose.
Contraindications
Individual hypersensitivity to components of the medicine.
Special Precautions
Medicine contains lactose. Patients with rare hereditary problems of galactose intolerance, the lactase deficiency or glucose-galactose malabsorption should not take this medicine.
No need to modify treatment for patients with renal or hepatic impairment.
Effects on ability to drive and use machines: Anaferon for children has no influence on the ability to drive and use machines.
Use In Pregnancy & Lactation
There were no special clinical studies of Anaferon on woman in period of pregnancy or lactation.
Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition of postnatal development.
Caution should be exercised when prescribing to pregnant women.
Adverse Reactions
No side effects have been reported for the drug used in accordance with the specified indications in the recommended doses.
Individual hypersensitivity to components of the medicine is possible.
Inform doctors of any unwanted effects related to drug use.
Drug Interactions
Cases of incompatibility with other medicines have not been reported. If necessary the drug can be co-administered with other antiviral, antibacterial and symptomatic drugs.
Storage
Store in dry light-protected place at temperature below 30°C.
Store in the original package.
Shelf life: 3 years since the manufacturing date.
ATC Classification
L03AB03 - interferon gamma ; Belongs to the class of interferons. Used as immunostimulants.
Presentation/Packing
Orodispersible tab 3 mg (white to off-white, round, flat, scored on one side and beveled, marked "MATERIA MEDICA" on one side and "ANAFERON KID" on the other) x 20's.
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