Ascorbic acid


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Scurvy
Adult: ≥240 mg daily in divided doses. For preventive therapy, 25-75 mg daily.
Child: 100-300 mg daily. For preventive therapy: Same as adult dose.

Parenteral
Scurvy
Adult: 0.5-1 g daily. For preventive therapy, 200-500 mg daily. Doses are given via IM, IV or SC inj.
Child: For curative therapy: 100-300 mg daily. For protective therapy: 30 mg daily. Doses are given via IM, IV or SC inj.
Renal Impairment
ESRD: 60-100 mg once daily.
Cách dùng
May be taken with or without food.
Hướng dẫn pha thuốc
IV inj: Dilute w/ large volume of glucose or normal saline.
Tương kỵ
Incompatible w/ ferric salts, oxidising agents, salts of heavy metals, particularly copper. Y-site admin: Incompatible w/ etomidate, propofol, thiopental. Syringe: Incompatible w/ cefazolin, doxapram, aminophylline, bleomycin sulfate, erythromycin, nitrufurantoin, sodium bicarbonate, nafcillin Na, sulfafurazole diethanolamine.
Thận trọng
Patient w/ hyperoxaluria, G6PD deficiency, DM, haemochromatosis. Renal impairment (e.g. renal failure, renal calculi). Pregnancy and lactation.
Phản ứng phụ
GI disturbances (e.g. diarrhoea, nausea, vomiting, abdominal cramps, transient colic, flatulent distention), heartburn, fatigue, flushing, headache, insomnia, sleepiness; hyperoxaluria, renal Ca oxalate calculi formation; temporary faintness/dizziness (IV); transient mild soreness at the site of inj (IM/SC).
IM/IV/Parenteral/PO/SC: C
Quá liều
Symptoms: Diarrhoea, hyperoxaluria, renal Ca oxalate calculi formation. Management: Symptomatic treatment.
Tương tác
Induced tissue desaturation w/ aspirin, nicotine, Fe, phenytoin, tetracycline estrogen from OCs, and some appetite suppressants and anticonvulsant drugs. Reduced absorption and decreased urinary excretion w/ aspirin. Reduced serum levels w/ OCs. May cause unexpected renal tubular reabsorption of acidic drugs and decreased reabsorption of basic drugs. May reduce response to oral anticoagulants. May decrease plasma concentration of fluphenazine. May worsen Fe toxicity to the heart w/ desferrioxamine.
Food Interaction
Induced tissue desaturation w/ alcohol.
Lab Interference
False-negative results from plasma, stool occult blood (48-72 hr after ingestion), and urinary glucose test.
Tác dụng
Description: Ascorbic acid, a water-soluble vitamin, acts as a cofactor and antioxidant. It is essential for tissue repair and formation of collagen and intercellular materials. Additionally, it is involved in conversion of folic acid to folinic acid, synthesis of lipids and proteins, carbohydrate metabolism, iron absorption and storage, and cellular respiration.
Onset: Scurvy symptoms reversal: 2 days to 3 wk.
Pharmacokinetics:
Absorption: Readily absorbed from the GI tract.
Distribution: Widely distributed in the body tissues. Crosses the placenta and enters breast milk. Plasma protein binding: Approx 25%.
Metabolism: Reversibly oxidised to dehydroascorbic acid (DHA), some are metabolised to the inactive metabolites, ascorbate-2-sulfate and oxalic acid.
Excretion: Via urine (as unchanged drug and as inactive metabolites). Elimination half-life: 10 hr.
Đặc tính

Chemical Structure Image
Ascorbic acid

Source: National Center for Biotechnology Information. PubChem Database. Ascorbic acid, CID=54670067, https://pubchem.ncbi.nlm.nih.gov/compound/Ascorbic-acid (accessed on Jan. 21, 2020)

Bảo quản
Tab/cap/liq: Store at room temp. Soln for inj: Store below 25°C. Protect from light. Do not freeze.
Phân loại MIMS
Phân loại ATC
A11GA01 - ascorbic acid (vit C) ; Belongs to the class of ascorbic acid (vitamin C). Used as dietary supplements.
References
Anon. Ascorbic Acid. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/10/2016.

Ascorbic Acid Injection, Solution (American Regent, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 06/10/2016.

Buckingham R (ed). Vitamin C Substances. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/10/2016.

Joint Formulary Committee. Ascorbic Acid (Vitamin C). British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/10/2016.

McEvoy GK, Snow EK, Miller J et al (eds). Ascorbic Acid, Calcium Ascorbate. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 06/10/2016.

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