Ascorbic acid


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Scurvy
Adult: As treatment: Not less than 250 mg daily in divided doses. Max: 1000 mg daily. As prophylaxis: 25-75 mg daily. Doses are individualised according to patient’s needs. Dosage recommendation may vary among countries or individual products. Refer to specific product guidelines.
Child: Dosage recommendation may vary among countries or individual products. Refer to specific product guidelines.

Parenteral
Scurvy
Adult: 300-1000 mg daily, given via IM, IV or SC inj. Doses are individualised according to patient's needs. Dosage recommendation may vary among countries or individual products. Refer to specific product guidelines.
Child: Initially, 100-300 mg daily in divided doses for 1 week then 100 mg daily until stabilisation of tissue saturation. Dosage recommendation may vary among countries or individual products. Refer to specific product guidelines.
Cách dùng
May be taken with or without food.
Hướng dẫn pha thuốc
IV: Add a daily dose to an appropriate volume of suitable solution (e.g. 5% dextrose in water, sterile water for inj). Add the solutes as necessary to make the final solution isotonic. Instructions for reconstitution may vary among countries or individual products. Refer to specific product guidelines.
Tương kỵ
Parenteral: Incompatible with ferric salts, oxidising agents, salts of heavy metals (e.g. Cu), aminophylline, bleomycin sulfate, erythromycin lactobionate, nafcillin Na, nitrofurantoin Na, conjugated estrogens, Na bicarbonate, sulfafurazole diethanolamine. Occasionally, chloramphenicol Na succinate (depending on pH or concentration).
Thận trọng
Patient with diabetes mellitus, G6PD deficiency, haemochromatosis, history of renal stones (e.g. oxalate kidney stones), predisposition to recurrent renal calculi. Renal impairment. Children (<2 years of age) and elderly. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Acute or chronic oxalate nephropathy (prolonged use; large doses).
Gastrointestinal disorders: Diarrhoea, nausea, vomiting, heartburn.
General disorders and administration site conditions: Fatigue, pain at the inj site.
Nervous system disorders: Dizziness, headache.
Vascular disorders: Flushing.
IM/IV/Parenteral/PO/SC: C
Chỉ số theo dõi
Monitor renal function (patient with a predisposition to oxalate nephropathy), haemoglobin, and blood counts (G6PD deficient patient).
Quá liều
Symptoms: Diarrhoea, formation of renal oxalate calculi. Management: Supportive and symptomatic treatment.
Tương tác
Increased absorption of Fe. Increased excretion of Fe with desferrioxamine. Induced tissue desaturation with aspirin, nicotine, Fe, phenytoin, tetracycline, estrogen in oral contraceptives, some appetite suppressants and anticonvulsants. May increase the absorption of Al-containing antacids. May diminish the activity of anticoagulants (e.g. warfarin). May increase the serum concentration of estrogen derivatives. May decrease the serum concentration of amphetamines.
Tương tác với thức ăn
Alcohol may decrease ascorbic acid levels.
Ảnh hưởng đến kết quả xét nghiệm
May interfere test results based on oxidation-reduction reactions (e.g. leucocyte count, blood and urine glucose testing, nitrite and bilirubin levels). May cause false-negative faecal occult blood test.
Tác dụng
Description: Ascorbic acid, a water-soluble vitamin that acts as a cofactor and as an antioxidant. It is essential for connective tissue synthesis, and Fe absorption and storage. Additionally, it is an electron donor used for collagen hydroxylation, carnitine biosynthesis, and hormone or amino acid synthesis.
Synonym: vitamin C.
Onset: 2 days to 3 weeks (reversal of scurvy symptoms).
Pharmacokinetics:
Absorption: Well absorbed from the gastrointestinal tract. Bioavailability: Approx 100% (Oral: for doses up to 200 mg).
Distribution: Crosses the placenta, enters breast milk. Widely distributed in the body tissues; distributed to the pituitary and adrenal glands, eye tissues and humours, leucocytes, and brain; low concentration in the plasma and saliva.
Metabolism: Reversibly metabolised via oxidation into dehydroascorbic acid (active), partly metabolised to inactive compounds including ascorbic-acid-2-sulfate and oxalic acid.
Excretion: Via urine (with high concentrations); minimal excretion in subthreshold levels (up to 80 mg/day). Elimination half-life: 10 hours.
Đặc tính

Chemical Structure Image
Ascorbic acid

Source: National Center for Biotechnology Information. PubChem Database. Ascorbic acid, CID=54670067, https://pubchem.ncbi.nlm.nih.gov/compound/Ascorbic-acid (accessed on Jan. 21, 2020)

Bảo quản
Oral: Store below 25°C. Protect from light and moisture. Parenteral: Store between 2-8°C. Protect from light.
Phân loại MIMS
Vitamin C
Phân loại ATC
A11GA01 - ascorbic acid (vit C) ; Belongs to the class of ascorbic acid (vitamin C). Used as dietary supplements.
Tài liệu tham khảo
Anon. Ascorbic Acid. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 20/04/2021.

Anon. Ascorbic Acid. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 20/04/2021.

Ascor Injection (McGuff Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 20/04/2021.

Ascorbic Acid 100 mg Tablets (Crescent Pharma Limited). MHRA. https://products.mhra.gov.uk. Accessed 20/04/2021.

Ascorbic Acid 200 mg Tablets (Ennogen Pharma Limited). MHRA. https://products.mhra.gov.uk. Accessed 20/04/2021.

Ascorbic Acid 50 mg Tablets BP (Dalkeith Laboratories Ltd). MHRA. https://products.mhra.gov.uk. Accessed 20/04/2021.

Ascorbic Acid 500 mg Tablets (Ennogen Pharma Limited). MHRA. https://products.mhra.gov.uk. Accessed 20/04/2021.

Ascorbic Acid Injection BPC 500 mg/5 mL (Phoenix Labs). MHRA. https://products.mhra.gov.uk. Accessed 20/04/2021.

Buckingham R (ed). Vitamin C Substances. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/04/2021.

Center for Advanced Medicine Ltd. Ascor L 500 data sheet 27 June 2018. Medsafe. http://www.medsafe.govt.nz. Accessed 20/04/2021.

Joint Formulary Committee. Ascorbic Acid (Vitamin C). British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 20/04/2021.

Leonas Vitamin C Tablet, Chewable (Leosons Overseas Corp). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 20/04/2021.

Vitamin C Tablet (Marlex Pharmaceuticals Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 20/04/2021.

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