Azicine

Azicine Tác dụng

azithromycin

Nhà sản xuất:

Stellapharm

Nhà phân phối:

Khuong Duy
Thông tin kê toa chi tiết tiếng Anh
Action
Pharmacotherapeutic group: Antibacterial for systemic use; Macrolides. ATC code: J01FA10.
Pharmacology: Pharmacodynamics: Azithromycin is a macrolide antibiotic belonging to the azalide group. The mechanism of action of azithromycin is based upon the suppression of bacterial protein synthesis by means of binding to the ribosomal 50S subunit and inhibition of peptide translocation.
Azithromycin susceptibility breakpoints for typical bacterial pathogens are: Aerobic Gram-positive microorganisms: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes.
Aerobic Gram-negative microorganisms: Haemophilus influenzae, Haemophilus parainfluenzae, Legionella pneumophila, Moraxella catarrhalis, Pasteurella multocida.
Anaerobic microorganisms: Clostridium perfringens, Fusobacterium spp., Prevotella spp., Porphyromonas spp.
Other microorganisms: Chlamydia trachomatis.
Pharmacokinetics: Azithromycin given orally is about 40% bioavailable. Peak plasma concentrations are achieved 2 to 3 hours after a dose, but azithromycin is extensively distributed to the tissues, and tissue concentrations subsequently remain much higher than those in the blood; in contrast to most other antibacterials, plasma concentrations are therefore of little value as a guide to efficacy. High concentrations are taken up into white blood cells. There is little diffusion into the CSF when the meninges are not inflamed.
Small amounts of azithromycin are demethylated in the liver, and it is excreted in bile as unchanged drug and metabolites. About 6% of an oral dose is excreted in the urine. The terminal elimination half-life is about 68 hours.
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