Adult: Acute attack: 2.25 g tid, until remission occurs or up to 12 wk. Maintenance: 1.5 g bid, adjusted according to response. Max: 6 g daily. Child: 5-17 yr 750 mg tid or 2.25 g tid, treatment may continue for up to 8 wk.
Moderate to severe: Contraindicated.
cap: May be taken with or without food. May be swallowed whole or sprinkle entire contents on applesauce. Take mixt immediately; the contents may be chewed. Do not store for future use.
Chống chỉ định
Severe hepatic and moderate to severe renal impairment.
Patient w/ pyloric stenosis, asthma, bleeding disorders, active peptic ulcer disease. Mild to moderate hepatic and mild renal impairment or history of renal disease. Pregnancy and lactation.
Symptoms: Nausea, vomiting, diarrhoea. Management: Supportive and symptomatic treatment.
Increased risk of blood dyscrasias w/ azathioprine and 6-mercaptopurine. Increased nephrotoxicity when used w/ NSAIDs. May decreased serum concentration of cardiac glycosides.
Description: Balsalazide is a prodrug of mesalazine which is linked to 4-aminobenzoyl-β-alanine via an azo bond. W/ the release of mesalazine, it reduces inflammation by inhibiting cyclooxygenase and leukotriene synthesis, thus blocking the formation of arachidonic acid in the colonic mucosa. Pharmacokinetics: Absorption: Time to peak plasma concentration: 1-2 hr (balsalazide); 9-10hr (mesalazine). Distribution: Plasma protein binding: Approx 99%. Metabolism: Undergoes bacterial azoreduction in the colon to 5-aminosalicylic acid (mesalazine, active), 4-aminobenzoyl-β-alanine (inert), and N-acetylated metabolites; 4-aminobenzoylalanine undergoes hepatic first-pass metabolism. Excretion: Mainly via faeces (approx 65%, as mesalazine, 4-aminobenzoyl-β-alanine or N-acetylated metabolites); urine (approx 25%, as N-acetylated metabolites); <1% via urine or faeces (as unchanged drug). Elimination half-life: 6-9 hr (as N-acetylated metabolites); approx. 1 hr (mesalazine).
A07EC04 - balsalazide ; Belongs to the class of aminosalicylic acid and similar antiinflammatory. Used in the treatment of intestinal inflammation.
Tài liệu tham khảo
Anon. Balsalazide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/08/2016.Balsalazide disodium capsule (Apotex Corp.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 03/08/2016.Buckingham R (ed). Balsalazide sodium. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/08/2016.Joint Formulary Committee. Balsalazide sodium. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/08/2016.McEvoy GK, Snow EK, Miller J et al (eds). Balsalazide disodium. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 03/08/2016.