Benzoyl peroxide


Thông tin thuốc gốc
Chỉ định và Liều dùng
Topical/Cutaneous
Acne vulgaris
Adult: As 2.5-10% preparations: Apply or use 1-2 times daily or as directed to the affected areas. May initiate treatment with lower strength preparations. Dosage recommendations and directions for use may vary among individual products (refer to specific product guideline).
Child: ≥12 years Same as adult dose. Recommendations for use in children may vary among individual products (refer to specific product guidelines for further information).
Chống chỉ định
Hypersensitivity.
Thận trọng
Application to the neck and other sensitive areas. Concomitant use with other topical acne therapy. Children. Pregnancy and lactation.
Phản ứng phụ
Significant: Increased sensitivity to sunlight, skin peeling, redness, swelling, or dryness; mild burning sensation.
Skin and subcutaneous tissue disorders: Allergic contact dermatitis.
Potentially Fatal: Rarely, allergic reactions, severe irritation.
Thông tin tư vấn bệnh nhân
Avoid contact with eyes, eyelids, mouth, lips, and other mucous membranes, or broken skin. Avoid deliberate or prolonged exposure to sunlight or UV radiation; use sunscreen and wear protective clothing. May bleach hair and coloured fabrics; avoid contact with hair, clothing, furniture or carpeting.
Quá liều
Symptom: Severe skin irritation. Management: Symptomatic treatment. Discontinue use and apply cold compress.
Tương tác
May reduce the efficacy of tretinoin, isotretinoin, and tazarotene. May result in temporary skin and facial hair discolouration (yellow/orange) when used concomitantly with sulfonamide- or sulfone-containing products.
Tác dụng
Description: Benzoyl peroxide is a highly lipophilic oxidising agent that has mild keratolytic effect and antimicrobial activity against Staphylococcus epidermidis and Propionibacterium acnes. Its antibacterial activity is due to the release of free-radical oxygen which oxidises bacterial protein in the sebaceous follicles reducing the number of anaerobic bacteria and irritating-type free fatty acids.
Pharmacokinetics:
Absorption: Approx 5% is absorbed through the skin.
Metabolism: Metabolised in the skin to benzoic acid.
Excretion: Via urine.
Đặc tính

Chemical Structure Image
Benzoyl Peroxide

Source: National Center for Biotechnology Information. PubChem Database. Benzoyl peroxide, CID=7187, https://pubchem.ncbi.nlm.nih.gov/compound/Benzoyl-peroxide (accessed on Jan. 21, 2020)

Bảo quản
Store between 15-30°C. Storage recommendations may vary among individual products. Refer to specific product guideline.
Phân loại MIMS
Phân loại ATC
D10AE01 - benzoyl peroxide ; Belongs to the class of topical peroxide preparations used in the treatment of acne.
References
111 Medco Benzoyl Peroxide Soap (111 Medco, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 22/03/2021.

Acnecide 5% w/w Gel (Galderma [UK] Limited). MHRA. https://products.mhra.gov.uk. Accessed 19/03/2021.

Anon. Benzoyl Peroxide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 03/02/2021.

Benzac AC (Galderma Hong Kong Ltd). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 22/03/2021.

Buckingham R (ed). Benzoyl Peroxide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/02/2021.

Enzoderm 5% Gel (Dermal Laboratories). MHRA. https://products.mhra.gov.uk. Accessed 19/03/2021.

Joint Formulary Committee. Benzoyl Peroxide. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 03/02/2021.

Neutrogena Acne Control Lotion (Johnson & Johnson Consumer Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

Neutrogena Clear Pore Cleanser Mask (Johnson & Johnson Consumer Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

Oxy Cover Cream (Rohto-Mentholatum [M] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 22/03/2021.

Oxy Lotion (Rohto-Mentholatum [M] Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 22/03/2021.

PanOxyl 5 Cream (GlaxoSmithKline Consumer Healthcare UK Trading Limited). MHRA. https://products.mhra.gov.uk. Accessed 03/02/2021.

PanOxyl Aquagel 2.5% w/w Gel (GlaxoSmithKline Consumer Healthcare UK Trading Limited). MHRA. https://products.mhra.gov.uk. Accessed 03/02/2021.

Panoxyl Cream (Crown Laboratories). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

Panoxyl Soap (Physicians Total Care, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 03/02/2021.

PanOxyl Wash 10% w/w Lotion (GlaxoSmithKline Consumer Healthcare UK Trading Limited). MHRA. https://products.mhra.gov.uk. Accessed 03/02/2021.

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  • Acnecide
  • Benzac AC
  • Cutacnyl
  • Eclaran 5
  • Oxy
  • PanOxyl
  • Perobar
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