Betamethasone + Clioquinol


Thông tin thuốc gốc
Chỉ định và Liều dùng
Topical/Cutaneous
Bacterial skin infections, Inflammatory skin conditions, Skin fungal infections
Adult: Available preparation:
Each 1 g of oint/cream contains betamethasone 1.22 mg and clioquinol 30 mg
Apply thinly and rub gently onto affected area(s) bid or tid, may reduce to once daily if condition improves.
Child: Same as adult dose. Max duration of therapy: 5 days.
Chống chỉ định
Rosacea, acne vulgaris, perioral dermatitis, iodine sensitivity, perianal or genital pruritus, napkin eruptions, dermatitis, pruritus w/o inflammation, primary viral (e.g. herpes simplex, chicken pox), fungal, bacterial, or yeast infections, dermatoses in childn <1 yr.
Thận trọng
Patient w/ psoriasis. Childn. Pregnancy and lactation.
Phản ứng phụ
Significant: Local hypersensitivity reactions; HPA axis suppression (e.g. Cushing’s syndrome), adrenal insufficiency, facial atrophic changes (long-term use); cataract, glaucoma; psoriasis relapse and tolerance, pustular psoriasis and systemic toxicity; prolonged local infection, risk of neurotoxicity (clioquinol).
Dermatologic: Burning, pruritus, pain, pigmentation changes, allergic contact dermatitis, hypertrichosis.
Thông tin tư vấn bệnh nhân
This drug may cause discolouration of skin, hair and cloth. Avoid long term use and abrupt withdrawal. Avoid use of occlusive dressing. Avoid application to the eyes.
Monitoring Parameters
Monitor for hypothalamic-pituitary adrenal (HPA) axis and adrenal insufficiency.
Lab Interference
Betamethasone: May suppress the wheal and flare reaction to skin antigens.Clioquinol: May interfere w/ thyroid function tests [e.g. radioactive iodine and butanol extractable iodine, protein-bound iodine (PBI)]. May cause false-positive ferric chloride test for phenylketonuria.
Tác dụng
Description: Betamethasone is a corticosteroid w/ mainly glucocorticoid activity. It has anti-inflammatory, antipruritic and vasoconstrictive properties. It depresses the formation, release and activity of inflammatory mediators (e.g. kinins, histamine, prostaglandins) by induction of phospholipase A2 inhibitory proteins (e.g. lipocortins) and inhibition of arachidonic acid release.
Clioquinol is a halogenated hydroxyquinoline derivative. It has a broad spectrum of activity against fungi (e.g. candida, microsporum, trichophyton); and bacteriostatic against gm+ve bacteria (e.g. staphylococci) but has limited activity against gm-ve bacterias.
Pharmacokinetics:
Absorption: Betamethasone: Readily absorbed from the intact skin.
Clioquinol: Approx 1.5-4% is absorbed.
Distribution: Betamethasone: Rapidly distributed to all body tissues. Crosses the placenta and enters breast milk (small amounts). Plasma protein binding: Extensively bound mainly to globulin.
Metabolism: Betamethasone: Metabolised in the liver.
Excretion: Betamethasone: Via urine and faeces.
Clioquinol: Via urine mainly as glucuronide, and as sulphate metabolites (small amounts).
Đặc tính

Chemical Structure Image
Betamethasone

Source: National Center for Biotechnology Information. PubChem Database. Betamethasone, CID=9782, https://pubchem.ncbi.nlm.nih.gov/compound/Betamethasone (accessed on Jan. 21, 2020)


Chemical Structure Image
Clioquinol

Source: National Center for Biotechnology Information. PubChem Database. Clioquinol, CID=2788, https://pubchem.ncbi.nlm.nih.gov/compound/Clioquinol (accessed on Jan. 21, 2020)

Bảo quản
Store below 30°C.
References
AFT Pharmaceuticals Ltd. Locorten Vioform Ear Drops data sheet September 2016. Medsafe. http://www.medsafe.govt.nz/. Accessed 14/09/2017.

Anon. Betamethasone (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 14/09/2017.

Betamethasone valerate/Clioquinol 1 mg/30 mg/g Cream (Chemidex Pharma Limited). MHRA. https://products.mhra.gov.uk/. Accessed 13/09/2017.

Betamethasone valerate/Clioquinol 1 mg/30 mg/g Ointment (Chemidex Pharma Limited). MHRA . https://products.mhra.gov.uk/. Accessed 13/09/2017.

Buckingham R (ed). Betamethasone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/09/2017.

Buckingham R (ed). Clioquinol. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/09/2017.

Buckingham R (ed). Pharmacokinetics of Corticosteroids. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 14/09/2017.

GlaxoSmithKline NZ Limited. Betnovate-C Cream and Ointment data sheet 11 December 2012. Medsafe. http://www.medsafe.govt.nz/. Accessed 13/09/2017.

Joint Formulary Committee. Betamethasone with Clioquinol. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/09/2017.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Betamethasone + Clioquinol từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2021 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in