Betamethasone + Gentamicin


Thông tin thuốc gốc
Chỉ định và Liều dùng
Topical/Cutaneous
Corticosteroid-responsive dermatoses with secondary infection
Adult: Available preparation:
Betamethasone 0.5 mg (0.05%) and gentamicin 1 mg (0.1%) cream or ointment

Apply a thin film onto affected area bid. Duration of treatment varies according to patient response and extent and location of disease. Reassess diagnosis, if no clinical improvement after 3-4 weeks.
Chống chỉ định
Hypersensitivity. Viral diseases (e.g. varicella, herpes simplex, vaccinia), TB of the skin.
Thận trọng
Pregnancy and lactation.
Phản ứng phụ
Significant: Adrenal suppression (particularly when used in younger children or patients receiving high doses for prolonged periods), allergic contact dermatitis, hypersensitivity reactions, local sensitisation (redness, irritation), secondary bacterial or fungal superinfection (prolonged use), visual disturbances (e.g. blurred vision), posterior subcapsular cataracts, glaucoma, hyperglycaemia, glycosuria; delayed weight gain, intracranial hypertension, growth retardation in children. Rarely, Cushing syndrome, central serous chorioretinopathy.
Skin and subcutaneous tissue disorders: Rash, dryness, burning, itching, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, skin atrophy, striae, miliaria, maceration of the skin.
Monitoring Parameters
Monitor HPA axis suppression and adrenal insufficiency (particularly in children), ocular symptoms.
Lab Interference
Betamethasone: May suppress the flare and wheal reactions to skin test antigens.
Tác dụng
Description: Betamethasone is a corticosteroid that has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces the phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, thus leading to reduction of the formation, release, and activity of endogenous chemical mediators of inflammation (e.g. kinins, histamine, prostaglandins, liposomal enzymes).
Gentamicin is a broad-spectrum aminoglycoside antibiotic which interferes with the bacterial protein synthesis by binding to the 30S and 50S ribosomal subunit of susceptible bacteria, thus rendering the bacterial cell membrane defective.
Pharmacokinetics:
Absorption: Betamethasone: Absorbed percutaneously (variable).
Gentamicin: Absorbed (systemic) following topical administration on denuded skin and burns.
Metabolism: Betamethasone: Metabolised in the liver.
Excretion: Betamethasone: Via urine and bile.
Đặc tính

Chemical Structure Image
Betamethasone

Source: National Center for Biotechnology Information. PubChem Database. Betamethasone, CID=9782, https://pubchem.ncbi.nlm.nih.gov/compound/Betamethasone (accessed on Jan. 21, 2020)


Chemical Structure Image
Gentamicin

Source: National Center for Biotechnology Information. PubChem Database. Gentamicin, CID=3467, https://pubchem.ncbi.nlm.nih.gov/compound/Gentamicin (accessed on Jan. 22, 2020)

Bảo quản
Store below 30°C. Protect from strong light.
Phân loại ATC
D07CC01 - betamethasone and antibiotics ; Belongs to the class of potent (group III) corticosteroids, in combination with antibiotics. Used in the treatment of dermatological diseases.
References
Anon. Betamethasone (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/04/2021.

Anon. Betamethasone and Gentamicin. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/04/2021.

Anon. Gentamicin (Topical). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/04/2021.

Beprogent Ointment/Cream (HOE Pharmaceuticals Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 07/04/2021.

Buckingham R (ed). Betamethasone. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/04/2021.

Buckingham R (ed). Gentamicin Sulfate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/04/2021.

Diprogenta Cream and Ointment (Merck Sharp & Dohme [Malaysia] Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 07/04/2021.

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