Betamethasone + Neomycin


Thông tin thuốc gốc
Chỉ định và Liều dùng
Ophthalmic
Ocular inflammation with suspected or confirmed bacterial infection
Adult: As ophthalmic ointment containing betamethasone Na phosphate 0.1% w/w and neomycin sulfate 0.5% w/w: Apply ¼ inch long to the lower eye lid 2-3 times daily and/or at night. Usual treatment duration: Up to 7 days per course.

Topical/Cutaneous
Corticosteroid-responsive dermatoses with secondary infection
Adult: As betamethasone (valerate) crm/oint containing 0.122% w/w and neomycin sulfate 0.5% w/w: Apply onto the affected area(s) 2-3 times daily.
Child: ≥2 yr: As cream/ointment containing betamethasone (as valerate) 0.122% w/w and neomycin sulfate 0.5% w/w: Apply onto the affected area(s) 2-3 times daily. Usual treatment duration: Up to 5 days/course.
Renal Impairment
Topical/Cutaneous:
Dose reduction may be necessary.
Chống chỉ định
Hypersensitivity. Rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus and primary cutaneous viral infections. Not to be used in otitis externa complicated by ear-drum perforation. Treatment of primary infected skin lesions caused by fungi or bacteria; primary or secondary infections due to yeast; or secondary infections due to Pseudomonas or Proteus species. Children <2 yr. Ophthalmic preparation: Not to be used in patients with glaucoma or herpetic keratitis.
Thận trọng
Avoid prolonged treatment as it may lead to systemic corticosteroid effects even withour occlusion. Avoid prolonged excessive application to the facial areas. Withdraw treatment if there is spread of the infection. Risk of glaucoma development if preparation enters eye(s). Regular monitoring is recommended when used in psoriasis due to treatment tolerance, rebound relapses, generalised pustular psoriasis or systemic toxicity. Increased risk of contact sensitisation when used for extended period or recurrently. Pregnancy and lactation. Ophthalmic preparation: Monitor intraocular pressure, cataract formation of unsuspected infections; evaluate treatment if there is no clinical improvement after 7 days. Not to be used for undiagnosed red eye.
Phản ứng phụ
Prolonged use may cause local atrophic changes in the skin e.g. thining, striae and dilatation of superficial blood vessels. Local skin burning sensation, pruritus, pigmentation changes, allergic contact dermatitis and hypertrichosis. Ophthalmic preparation: Corneal ulceration, increased intraocular pressure, mydriasis, ptosis, epithelial punctate keratitis.
Quá liều
Acute overdosage is unlikely to occur. Prolonged excessive use may lead to sufficient systemic absorption resulting in symptoms of Cushing's syndrome, in which case, gradual withdrawal of the drug is recommended. Significant systemic absorption of neomycin sulfate may cause ototoxicity and nephrotoxicity. Treatment involves withdrawal of drug and monitoring general status, hearing acuity, renal and neuromuscular functions of the patient.
Tương tác
If there is significant systemic absorption, neomycin sulfate may increase the respiratory depressant effects of neuromuscular blockers.
Tác dụng
Description: Betamethasone valerate is a corticosteroid which is effective in inflammatory dermatoses. It is also effective in less responsive conditions such as psoriasis. Neomycin sulfate is a broad spectrum antibiotic. It is bactericidal against many bacteria which are commonly associated with skin infections.
Pharmacokinetics:
Absorption: Betamethasone: Absorption through the skin depends on several factors e.g. presence of occlusive dressing, integrity of the epidermal barrier.
Distribution: Betamethasone: Bound to plasma proteins to varying extent.
Metabolism: Betamethasone: Largely metabolised hepatically.
Excretion: Betamethasone: Mainly excreted via the kidneys.
Bảo quản
Store <25°C.
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