Betaxolol


Thông tin thuốc gốc
Chỉ định và Liều dùng
Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: As 0.25% or 0.5% drops: Instill 1 drop bid.

Oral
Hypertension
Adult: Initially, 10 mg once daily, may increase to 20 mg/day after 1-2 wk if needed.
Elderly: Initially, 5 mg/day.
Renal Impairment
Oral:
Severe or on dialysis: Initially, 5 mg/day, may increase by increments of 5 mg every 2 wk. Max: 20 mg/day.
Cách dùng
May be taken with or without food.
Chống chỉ định
Sick sinus syndrome, severe bradycardia, cardiogenic shock, uncontrolled cardiac failure, 2nd or 3rd degree AV block, severe bronchial asthma, severe COPD, metabolic acidosis, untreated phaeochromocytoma, severe peripheral arterial disease.
Thận trọng
Patients w/ bronchospastic disease, DM, corneal disease. May mask signs of hyperthyroidism and acute hypoglycaemia. Avoid abrupt withdrawal as it may exacerbate angina, MI, ventricular arrhythmias and precipitate thyroid storm. Patients undergoing surgery involving general anaesth. Renal and hepatic impairment. Pregnancy and lactation.
Phản ứng phụ
Eye discomfort (stinging and burning), bradycardia, palpitation, chest pain, oedema, insomnia, fatigue, lethargy, nausea, dyspepsia, diarrhoea, arthralgia, paraesthesia, dyspnoea, pharyngitis, antinuclear antibody positive, cold extremities.
MonitoringParameters
Monitor BP, pulse and baseline renal function.
Quá liều
Symptoms: Symptomatic bradycardia, bronchospasm, hypotension and acute cardiac failure. Management: Perform gastric lavage. Administer IV atropine sulfate to induce vagal blockade; dopamine, dobutamine or norepinephrine for hypotension and glucagon for refractory cases; isoprenaline HCl and aminophylline for bronchospasm; conventional therapy w/ digitalis, diuretics and oxygen for acute cardiac failure.
Tương tác
Increased risk of bradycardia w/ digitalis glycosides. May cause mydriasis w/ epinephrine. Potential additive effect w/ oral Ca channel blockers, β-adrenergic blockers, antiarrhythmics (including amiodarone), parasympathomimetics, guanethidine. Increased risk of myocardial depression and hypotension w/ peripheral muscle relaxants (e.g. tubocurarine).
Food Interaction
May increase plasma levels w/ alcohol.
Lab Interference
May interfere result w/ glaucoma screening test (oral).
Tác dụng
Description: Betaxolol is a cardioselective β-blocker which has greater affinity for β1-receptors and has little or no effect on β2-receptors. It lacks intrinsic sympathomimetic but has little membrane-stabilising activity. It also causes the reduction of intraocular pressure by decreasing the production of aqueous humour.
Onset: 1-1.5 hr (oral).
Pharmacokinetics:
Absorption: Completely absorbed from the GI tract. Oral bioavailability: Approx 90%.
Distribution: Crosses the placenta and is distributed into the breast milk. Plasma protein binding: Approx 50%.  
Metabolism: Undergoes minimal first-pass metabolism.
Excretion: Via urine (approx 15% as unchanged drug). Elimination half-life: 14-22 hr.
Bảo quản
Store between 15-25°C.
References
Anon. Betaxolol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/12/2013.

Batxolol tablet (Epic Pharma). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/12/2013.

Buckingham R (ed). Betaxolol hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/12/2013.

Kerlone Tablet. U.S. FDA. https://www.fda.gov/. Accessed 04/12/2013.

McEvoy GK, Snow EK, Miller J et al (eds). Betaxolol hydrochloride (EENT). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 04/12/2013.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Betaxolol từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2021 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
  • Betoptic S
  • Iobet
  • Kerlone
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in