Biperiden


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Drug-induced extrapyramidal symptoms
Adult: 2 mg 1-3 times daily. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).

Oral
Parkinsonism
Adult: Initially, 1 mg bid, may be increased gradually according to patient's needs. Max: 16 mg daily. Dosage recommendations may vary among countries and individual products (refer to specific product guidelines).
Cách dùng
Should be taken with food.
Chống chỉ định
Narrow-angle glaucoma, megacolon, bowel obstruction, paralytic ileus.
Thận trọng
Patient with cardiac failure, tachycardia or cardiac arrhythmias, history of seizure disorder; hyperthyroidism, prostatic hyperplasia and/or urinary stricture or retention, myasthenia gravis. Not recommended for use in patients with tardive dyskinesia. Renal and hepatic impairment. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Anhidrosis, hyperthermia; anticholinergic effects (e.g. blurred vision, constipation, xerostomia, urinary retention); CNS depression; confusion, hallucinations, delirium, anxiety, amnesia (usually at higher doses).
Cardiac disorders: Bradycardia.
Nervous system disorders: Drowsiness.
Psychiatric disorders: Sleep disorder (decreased rapid eye movement [REM] sleep and increased REM latency), agitation, disorientation, euphoria.
Vascular disorders: Postural hypotension.
Thông tin tư vấn bệnh nhân
This drug may cause CNS depression which may impair physical or mental abilities, if affected, do not drive or operate machinery.
Chỉ số theo dõi
Monitor IOP.
Quá liều
Symptoms: Mydriasis, dryness of mucous membranes, flushing, increased heart rate, decreased bowel motility, decreased ureter and bladder tone, increased temperature, excitation, confusion, clouding of consciousness and/or hallucinations. In severe cases, cardiac and respiratory depression may occur. Management: Supportive treatment. Gastric lavage or emesis may be considered. Acetylcholinesterase inhibitors may be given as antidote. Closely monitor vital signs. Fever reduction, application of catheter, and artificial ventilation may be needed. Cardiac stimulant (e.g. dobutamine) may be considered in case of cardiac depression.
Tương tác
Enhanced CNS and peripheral adverse effects with other anticholinergic psychotropic drugs, antihistamines, antispasmodics, and other antiparkinsonian agents. May potentiate anticholinergic effect (especially AV conduction) with quinidine. May enhance dyskinesia with levodopa. Reduced effect of metoclopramide and other compounds with similar activity on the gastrointestinal tract.
Tương tác với thức ăn
Alcohol may enhance the adverse effects of biperiden.
Tác dụng
Description:
Mechanism of Action: Biperiden is a predominantly central anticholinergic agent that helps balance cholinergic transmission in the basal ganglia. It has weak peripheral anticholinergic activity.
Pharmacokinetics:
Absorption: Readily absorbed from the gastrointestinal tract. Bioavailability: Approx 30%. Time to peak plasma concentration: 0.8-1.6 hours.
Distribution: Plasma protein binding: 90-95%.
Metabolism: Undergoes extensive first-pass metabolism; metabolised via hydroxylation of bicycloheptene ring and piperidine ring.
Excretion: Elimination half-life: Approx 20 hours.
Đặc tính

Chemical Structure Image
Biperiden

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 2381, Biperiden. https://pubchem.ncbi.nlm.nih.gov/compound/Biperiden. Accessed Nov. 22, 2023.

Bảo quản
Store below 30°C. Protect from light.
Phân loại MIMS
Thuốc trị bệnh Parkinson
Phân loại ATC
N04AA02 - biperiden ; Belongs to the class of tertiary amines anticholinergic agents. Used in the management of Parkinson's disease.
Tài liệu tham khảo
Anon. Biperiden. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 06/10/2023.

Apiden 2 mg Tablet (JF Draf Pharmaceuticals Corp.). MIMS Philippines. http://www.mims.com/philippines. Accessed 06/10/2023.

Biperiden. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases. https://www.ncbi.nlm.nih.gov/books/ NBK548257. Accessed 06/10/2023.

Buckingham R (ed). Biperiden. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 06/10/2023.

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