Known hypersensitivity to the active substance or any of the other excipients.
Active gastric or intestinal ulcer, bleeding or perforation (see PRECAUTIONS and also ADVERSE REACTIONS).
Last trimester of pregnancy (see USE IN PREGNANCY & LACTATION).
Severe hepatic failure.
Severe renal failure (GFR <15 mL/min/1.73m2).
Patients with congestive heart failure (from level II to level IV according to functional heart failure classification of New York Heart Association-NYHA), ischemic heart disease, peripheral arterial disease, cerebrovascular disease.
Like other non-steroidal anti-inflammatory drugs (NSAIDs), Cataflam is also contraindicated in patients in whom the use of acetylsalicylic acid or other NSAIDs can precipitate asthma, angioedema, urticaria, or acute rhinitis (i.e. NSAID-induced cross-reactivity reactions) (see PRECAUTIONS and also ADVERSE REACTIONS).
History of gastrointestinal bleeding or perforation, relating to previous NSAID therapy.