Adult: 600 mg daily as a single or in 2 divided doses for 5-10 days. Child: ≥6 mth 14 mg/kg daily as a single or in 2 divided doses. Max: 600 mg daily.
300 mg once daily.
May be taken with or without food.
Hướng dẫn pha thuốc
Reconstitute powd for oral susp at the time of dispensing by adding the amount of water specified on the container to provide a susp containing 125 mg or 250 mg per 5 mL. Add water in 2 equal parts, invert and shake the bottle after each addition.
Chống chỉ định
Hypersensitivity to cefdinir or other cephalosporins.
Patient w/ history of penicillin allergy and colitis. Renal impairment. Childn. Pregnancy and lactation.
Tác dụng không mong muốn
Diarrhoea, nausea, abdominal pain, vomiting, headache, skin rash, vulvovaginal candidiasis, proteinuria, elevated urine leukocytes, lymphocytosis, decreased serum bicarbonate, increased serum ALT and urine specific gravity. Potentially Fatal: Anaphylaxis, Clostridium difficile-associated diarrhoea and colitis.
Monitor renal function; observe for signs and symptoms of anaphylaxis during 1st dose.
Symptoms: Nausea, vomiting, epigastric distress, diarrhoea, convulsions. Management: Haemodialysis may be useful in the event of a serious toxic reaction particularly if renal function is compromised.
Concomitant admin w/ antacids or Fe supplements reduce the rate and extent of absorption. Admin w/ Fe supplements may cause reddish stools. Decreased renal elimination w/ probenecid.
Ảnh hưởng đến kết quả xét nghiệm
False-positive reaction for urinary ketones may occur w/ nitroprusside-based tests. False-positive urine glucose results may occur when using Clinitest®, Benedict's or Fehling's soln. May cause positive direct Coombs' test.
Description: Cefdinir binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Pharmacokinetics: Absorption: Absorbed from the GI tract. Bioavailability: Approx 16-25%. Time to peak plasma concentration: 2-4 hr. Distribution: Widely distributed into body tissues. Volume of distribution: 0.35 L/kg. Plasma protein binding: 60-70%. Metabolism: Minimal metabolism. Excretion: Via urine (approx 12-18% as unchanged drug). Elimination half-life: 1.7 hr.
Anon. Cefdinir. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 04/11/2014.Buckingham R (ed). Cefdinir. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 04/11/2014.Cefdinir capsule (Aurobindo Pharma Limited). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/11/2014.Cefdinir Powder for Suspension (Lupin Pharmaceuticals Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 04/11/2014.McEvoy GK, Snow EK, Miller J et al (eds). Cefdinir. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 04/11/2014.