Thông tin thuốc gốc
Chỉ định và Liều dùng
Uncomplicated gonorrhoea
Adult: 400 mg as a single dose.

Lower respiratory tract infections, Upper respiratory tract infections, Urinary tract infections
Adult: 200-400 mg as a single or in 2 divided doses daily, according to the severity of infection. Treatment duration: 7-14 days, depending on the type and severity of infection.
Child: 6 months to 10 years weighing <50 kg: As susp or chewable tab: 8 mg/kg daily as a single or in 2 divided doses; >10 years weighing >50 kg: Same as adult dose.
Suy thận
Upper respiratory tract infections; Lower respiratory tract infections; Urinary tract infections:
Patients undergoing continuous ambulatory peritoneal dialysis (CAPD) or haemodialysis: Max: 200 mg once daily.
CrCl (mL/min) Dosage
<20 Max: 200 mg once daily.

Cách dùng
May be taken with or without food. May be taken w/ food or milk to reduce GI discomfort.
Hướng dẫn pha thuốc
Powder for oral susp: Add the appropriate amount of water specified on the packaging in 2 portions. Shake well after each addition until contents are evenly suspended.
Chống chỉ định
Hypersensitivity to cephalosporins.
Thận trọng
Patient with history of hypersensitivity to penicillin and other beta-lactam antibiotics, poor nutritional state, history of gastrointestinal disease, particularly colitis. Renal and hepatic impairment. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Encephalopathy (including convulsion, confusion, impairment of consciousness, movement disorders), acute renal failure (including tubulointerstitial nephritis).
Blood and lymphatic system disorders: Transient thrombocytopenia, leucopenia, neutropenia, pancytopenia, agranulocytosis, eosinophilia.
Gastrointestinal disorders: Diarrhoea, loose or frequent stools, abdominal pain, nausea, vomiting, dyspepsia, flatulence.
Hepatobiliary disorders: Hepatitis, jaundice, hyperbilirubinaemia.
Immune system disorders: Hypersensitivity reactions including rash, pruritus, urticaria, drug fever.
Investigations: Transient elevations in SGPT, SGOT, alkaline phosphatase, BUN and creatinine; increased LDH. Rarely, prolonged prothrombin time.
Nervous system disorders: Headaches, dizziness, seizures.
Reproductive system and breast disorders: Genital pruritus, vaginitis, candidiasis.
Potentially Fatal: Severe cutaneous adverse reactions (SCARS) including toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), drug rash with eosinophilia and systemic symptoms (DRESS), and acute generalised exanthematous pustulosis (AGEP), haemolytic anaemia, pseudomembranous colitis, anaphylactic/anaphylactoid reactions (including shock).
Chỉ số theo dõi
Monitor renal and hepatic functions periodically. Observe for signs and symptoms of anaphylaxis during 1st dose.
Quá liều
Symptoms: Encephalopathy including convulsion, confusion, impaired consciousness and movement disorders. Management: General supportive treatment.
Tương tác
May enhance the effects of anticoagulants (e.g. warfarin) resulting in prolonged prothrombin time. May increase carbamazepine levels.
Ảnh hưởng đến kết quả xét nghiệm
May cause false-positive reaction for urinary glucose using Clinitest®, Benedict’s solution, or Fehling’s solution; false-positive reaction for ketones in the urine with tests using nitroprusside; false-positive direct Coombs’ test.
Tác dụng
Mechanism of Action: Cefixime is a 3rd generation cephalosporin with bactericidal activity. It binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell lysis and death.
Absorption: Bioavailability: 22-54%. Time to peak plasma concenration: 2-6 hours (susp); 3-8 hours (cap).
Distribution: Crosses the placenta. Plasma protein binding: Approx 65%, mainly to albumin.
Excretion: Mainly via urine (approx 50% as unchanged drug); faeces (10%).
Đặc tính

Chemical Structure Image

Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5362065, Cefixime. https://pubchem.ncbi.nlm.nih.gov/compound/5362065. Accessed Aug. 25, 2022.

Bảo quản
Store between 20-25°C. Reconstituted powder for oral susp: Store between 2-8°C, stable for up to 14 days.
Phân loại MIMS
Phân loại ATC
J01DD08 - cefixime ; Belongs to the class of third-generation cephalosporins. Used in the systemic treatment of infections.
Tài liệu tham khảo
Anon. Cefixime. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 13/07/2022.

Anon. Cefixime. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 13/07/2022.

Buckingham R (ed). Cefixime. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/07/2022.

Cefisal-200 200 mg Film-coated Tablet (Akums Drugs & Pharmaceuticals Ltd.). MIMS Philippines. http://www.mims.com/philippines. Accessed 13/07/2022.

Cefixime 100 mg/5 mL Powder for Oral Suspension (Generics UK Ltd t/a Mylan). MHRA. https://products.mhra.gov.uk. Accessed 13/07/2022.

Cefixime Capsule (Ascend Laboratories, LLC). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 13/07/2022.

Cefixime Powder for Suspension (Aurobindo Pharma Limited). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 13/07/2022.

Joint Formulary Committee. Cefixime. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/07/2022.

Suprax Tablet, Chewable (Lupin Pharma). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 13/07/2022.

Suprax Tablets 200 mg (Aventis Pharma Limited). MHRA. https://products.mhra.gov.uk. Accessed 13/07/2022.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Cefixime từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2024 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
  • Acicef
  • Afix/Cefixi
  • Akincef
  • Amyxim
  • Bactirid
  • Betafast
  • Bicebid
  • Bicefixim
  • Cadifixim
  • Cefco
  • Cefibiotic
  • CefiDHG
  • Cefiget
  • Cefimark
  • Cefimbrand
  • Cefimed
  • Cefimvid
  • Cefixim Cophavina
  • Cefixim DHG
  • Cefixim Glomed
  • Cefixim IBN
  • Cefixim Mebiphar
  • Cefixim TV Pharm
  • Cefixim Vidipha
  • Cefixime AMN
  • Cefixime Chem
  • Cefixime Flamingo
  • Cefixime Medico Remedies
  • Cefixime Minimed
  • Cefixime MKP
  • Cefixime Santa
  • Cefixime SRS
  • Cefixime Uphace
  • Cefixure
  • Ceflim
  • Cefmac
  • Cefmycin
  • Cefrin
  • Cefrub
  • Cefspan
  • Ceftacef 100/200/Sachet 100 mg
  • Ceftacef 50
  • Ceftacef LB
  • Ceftasintas
  • Ceftrimini
  • Cefxim
  • Cehan
  • Cemax
  • Cemixim
  • Cenfy
  • Ceracyxime
  • Cerat
  • Cerloby 200
  • Cerlocil
  • Cevezil
  • Cexime
  • Cifataze
  • Cifex
  • Cipcef 100/200
  • C-Marksans
  • Crocin
  • C-Tax T
  • Curecefix
  • Chemcef
  • Dahaxim
  • Dalaxim
  • Digoxim
  • Docifix
  • Docimax
  • Dorixina
  • Dorixna
  • Effixent
  • Efime
  • Efixime
  • Epixim
  • Essenxim
  • Euphoric
  • Eurfix
  • Euvixim
  • Evofix
  • Fasixime
  • Fecimfort
  • Fexim
  • Fimabute
  • Fiosaxim
  • Fithixime
  • Fixcap
  • Fixef
  • Fixim
  • Fiximstad
  • Fixkem-200
  • Fixkids
  • Fixma
  • Fixtin
  • Fixx
  • Flowmet
  • Focixime
  • Foxicime
  • Ganexime
  • Geof-Cefixime
  • Grancef
  • Habucefix
  • Hancef
  • Hancefix
  • Hanmiorofix
  • Helicef
  • Hepime
  • Holdafix
  • Hỗn dịch uống Cefixime
  • Hwafix
  • Ifex Capsule
  • Ikocef-100 DT
  • Imexime
  • Inbionetinfixim
  • Incef-200
  • Interfixim 200
  • Ixib
  • Ixifast
  • Kidfix
  • KwangMyungCefix
  • Lufixime
  • Macrebid
  • Macrocef
  • Mebixim
  • Mecefix-B.E
  • Minicef 100/200
  • Mitafix
  • Morecef
  • M-Xime
  • Myroken
  • Newcefix
  • Nisime
  • O-Powercef
  • Orafect
  • Oralxim
  • Orenko
  • Ormet
  • Orpase
  • Pedcefix
  • Pencid
  • Pentafex
  • Prioxime
  • Puraxim
  • Q-Tax
  • Refixime/Refixime-100
  • Rite-O-Cef
  • Robfixim
  • Ronafix
  • Safix
  • Santifex
  • Santifex-50
  • Savecef
  • Secef
  • Sidomix
  • Sitidomix
  • Sulfazicef
  • Sunxime
  • Sungwon Adcock Cefixime
  • Sungwon Adcock Cefixime Cap.
  • Swetacefix
  • Tifaxcin
  • Topcef/Torfexim
  • Torafix
  • Torfexim 100 DT
  • Tytxym
  • Tricef
  • Ukfix cap.
  • Umexim
  • Unifix
  • Unixim
  • Uphaxime
  • Viababyfixime
  • Vinfixxim
  • Vometis
  • Xival
  • Zotinat
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Already a member? Sign in