Clobetasol


Thông tin thuốc gốc
Chỉ định và Liều dùng
Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05% oint/cream/lotion/gel/scalp soln: Apply thinly and rub gently onto the affected area once daily or bid, reduced if necessary. Max dose: 50 g wkly. Max duration of therapy: 4 wk.
Child: >1 yr Same as adult dose. Max duration of therapy: 5 days.

Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05% foam: Apply to affected area bid. Max: 50g wkly. Max duration of therapy: 2 wk.

Topical/Cutaneous
Corticosteroid-responsive dermatoses
Adult: As 0.05% shampoo: Apply directly on dry scalp once daily, leave for 15 min. Do not cover w/ shower cap. Max duration of therapy: 4 wk.
Chống chỉ định
Untreated bacterial, fungal or viral skin lesions, rosacea, perioral dermatitis, acne, and plaque psoriasis. Childn <1 yr (oint/cream/lotion/gel/scalp soln); <2 yr (shampoo).
Thận trọng
Childn. Pregnancy and lactation.
Phản ứng phụ
Significant: Hypothalamic-pituitary-adrenal (HPA) axis suppression or hypercorticism (i.e. Cushing’s syndrome, hyperglycaemia, glycosuria), contact dermatitis, skin irritation.
Nervous: Numbness of fingers.
CV: Intracranial HTN e.g. bulging fontanelles, headaches, bilateral papilledema.
Dermatologic: Burning and stinging sensation, tingling, cracking, irritation, itching, dryness, hypopigmentation, maceration, erythema, folliculitis, perioral dermatitis, skin atrophy, acneiform, hypertrichosis, tenderness, telangiectasia, striae, miliaria, alopecia, pustules and tightening of the scalp.
Thông tin tư vấn bệnh nhân
Avoid use w/ occlusive dressing. Avoid contact w/ face (i.e. eyes, nose, mouth), axillae, or groin. Clobetasol foam is flammable, do not smoke during or immediately after application.
MonitoringParameters
Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression through ACTH stimulation test, morning plasma cortisol test, and urinary free cortisol test.
Tương tác
Increased systemic exposure w/ CYP3A4 enzyme inhibitors (e.g. itraconazole, ritonavir). May diminish the antineoplstic effect of aldesleukin. May potentiate the hyperglycaemic effect of ceritinib. May diminish the therapeutic effect of corticorelin and hyaluronidase. May enhance the adverse/toxic effects of deferasinox.
Tác dụng
Description: Clobetasol is a very potent topical glucocorticoid w/ anti-inflammatory, antipruritic, and vasoconstrictive effects. It promotes induction of phospholipase A2 inhibitory proteins (lipocortins), subsequently inhibiting the release of arachidonic acid, thereby depressing the formation, release, and activity of endogenous chemical mediators of inflammation (e.g. histamine, leukotrienes, prostaglandins).
Pharmacokinetics:
Absorption: Variable absorption depending on dose, integrity of epidermis, vehicle used, and use of occlusive dressing.
Distribution: Minimal distribution to the dermis.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.
Đặc tính

Chemical Structure Image
Clobetasol

Source: National Center for Biotechnology Information. PubChem Database. Clobetasol propionate, CID=32798, https://pubchem.ncbi.nlm.nih.gov/compound/Clobetasol-propionate (accessed on Jan. 21, 2020)

Bảo quản
Store between 20-25°C. Do not refrigerate.
Phân loại MIMS
Phân loại ATC
D07AD01 - clobetasol ; Belongs to the class of very potent (group IV) corticosteroids. Used in the treatment of dermatological diseases.
References
Anon. Clobetasol. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/03/2017.

Buckingham R (ed). Clobetasol Propionate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/03/2017.

Clobetasol Propionate Aerosol, Foam (DPT Laboratories, Ltd.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/03/2017.

Clobetasol Propionate Cream (Actavis Pharma, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/03/2017.

Clobetasol Propionate Gel (Hi-Tech Pharmacal Co., Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/03/2017.

Clobetasol Propionate Lotion (Teligent Pharma, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/03/2017.

Clobetasol Propionate Ointment (G&W Laboratories, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/03/2017.

Clobetasol Propionate Solution (Actavis Pharma, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/03/2017.

Joint Formulary Committee. Clobetasol Propionate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/03/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Clobetasol Propionate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/03/2017.

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