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Chỉ định và Liều dùng
Oral
Allergic conditions, Pruritic skin disorders Adult: Up to 6 mg daily in 3-4 divided doses.
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Chống chỉ định
Severe liver disease; avoid alcohol; premature infants or full-term neonates.
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Thận trọng
May impair ability to drive and operate machinery. Angle-closure glaucoma, urinary retention, prostatic hypertrophy or pyloroduodenal obstruction; epilepsy; hepatic impairment. Elderly. Pregnancy and lactation.
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Phản ứng phụ
Sedation; antimuscarinic effects, CNS depression and disturbances; occasionally, paradoxical CNS stimulation esp in child; psychomotor impairment; headache; palpitations and arrhythmias. Convulsions, sweating, myalgia, paraesthesias, extrapyramidal symptoms, tremor, sleep and GI disturbances, hypersensitivity reactions and blood disorders; tinnitus, hypotension; hair loss.
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Tương tác
Enhance effects of CNS depressants eg, alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Atropine, tricyclic antidepressants (TCAs), MAOIs. Can mask signs of ototoxicity caused by aminoglycosides. May antagonise the action of betahistine. Increased risk of seizure when used with bupropion. Concurrent use with mefloquine may lead to prolongation of the QT interval.
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Lab Interference
May interfere with skin testing.
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Tác dụng
Description: Diphenylpyraline, a piperidine derivative, is an antihistamine with antimuscarinic and significant sedative properties.
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