Erdosteine


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Acute exacerbations of chronic bronchitis, Acute respiratory disorders associated with excessive mucus production, Chronic respiratory disorders associated with excessive mucus production
Adult: As cap or dispersible tab: 300 mg bid or tid. Treatment duration for acute exacerbations of chronic bronchitis not to exceed 10 days. As susp: 350 mg bid. Dosing recommendations may vary among individual products or preparations and between countries (refer to specific product guidelines).
Child: As susp: 15-<20 kg: 175 mg bid; 20-30 kg: 175 mg tid; >30 kg: Same as adult dose. Dosing recommendations may vary among individual products or preparations and between countries (refer to specific product guidelines).
Suy thận
CrCl (mL/min) Dosage
<25 Contraindicated.
Suy gan
Mild to moderate: Max: 300 mg daily. Severe: Contraindicated.
Cách dùng
cap: May be taken with or without food.
Hướng dẫn pha thuốc
Powder for oral susp: Reconstitute with the appropriate volume of water, shake well.
Chống chỉ định
Active peptic ulcer. Severe renal (CrCl <25 mL/min) and hepatic impairment (including hepatic cirrhosis and cystathionine-synthase deficiency). Children (<2 years).
Thận trọng
Mild to moderate hepatic impairment. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Significant: Epigastric pain, taste alteration.
Gastrointestinal disorders: Diarrhoea, nausea, vomiting.
Immune system disorders: Angioedema, cutaneous hypersensitivity reactions (e.g. urticaria, oedema, erythema, eczema).
Nervous system disorders: Headache.
Respiratory, thoracic and mediastinal disorders: Cold, dyspnoea.
Quá liều
Symptoms: Dizziness, sweating, flushing. Management: Symptomatic and supportive treatment. May perform gastric lavage if necessary.
Tác dụng
Description: Erdosteine is a prodrug which becomes active after metabolism whereby free thiol groups are formed. This results in the opening of disulfide bonds in bronchial mucoproteins thus reducing mucous viscosity. Additionally, it inhibits bacterial adhesion to epithelial cells.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract. Time to peak plasma concentration: Approx 1 hour.
Distribution: Plasma protein binding: 50-86%.
Metabolism: Undergoes rapid first-pass metabolism to N-thiodiglycolyl-homocysteine (active metabolite).
Excretion: Via urine (as active metabolite and sulfates). Elimination half-life: 1.46 hours (erdosteine); 1.62 hours (N-thiodiglycolyl-homocysteine).
Đặc tính

Chemical Structure Image
Erdosteine

Source: National Center for Biotechnology Information. PubChem Database. Erdosteine, CID=65632, https://pubchem.ncbi.nlm.nih.gov/compound/Erdosteine (accessed on Jan. 22, 2020)

Bảo quản
Store below 30°C.
Phân loại MIMS
Thuốc ho & cảm
Phân loại ATC
R05CB15 - erdosteine ; Belongs to the class of mucolytics. Used in the treatment of wet cough.
Tài liệu tham khảo
Anon. Erdosteine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/10/2021.

Buckingham R (ed). Erdosteine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.new.medicinescomplete.com. Accessed 07/10/2021.

Ectrin (OEP Phils). MIMS Philippines. http://www.mims.com/philippines. Accessed 07/10/2021.

Erdomed 300 mg Hard Capsules; 300 mg Dispersible Tablets (Edmond Pharma S.r.l.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 07/10/2021.

Erdos Capsule 300 mg (Daewoong Pharmaceutical [Thailand] Co., Ltd.). MIMS Thailand. http://www.mims.com/thailand. Accessed 07/10/2021.

Erdotin 300 mg Capsules (Galen Limited). MHRA. https://products.mhra.gov.uk. Accessed 07/10/2021.

Joint Formulary Committee. Erdosteine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/10/2021.

Zertin 300 mg Capsule; 175 mg/5 mL Powder for Suspension (GlaxoSmithKline). MIMS Philippines. http://www.mims.com/philippines. Accessed 07/10/2021.

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