Ergocalciferol


Thông tin kê toa tóm tắt
Chỉ định/Công dụng
Listed in Dosage.
Liều dùng/Hướng dẫn sử dụng
Adult : PO Hypocalcaemia; Rickets or osteomalacia 10 mcg/day, up to 1 mg/day in severe deficiency.
Dosage Details
Oral
Hypocalcaemia, Rickets or osteomalacia
Adult: 10 mcg daily, up to 1 mg may be used in severe deficiency states such as malabsorption states or liver disease. May also be given via IM admin.
Chống chỉ định
Hypercalcaemia, evidence of vit D toxicity, malabsorption syndrome, hypervitaminosis D, abnormal sensitivity to vit D affects; decreased renal function.
Thận trọng
Serum Ca multiplied by phosphate >70 may lead to precipitation of Ca phosphate, hypersensitivity, renal function impairment. Patients with normal renal function must take adequate fluid intake to prevent dehydration. Monitor frequently serum and urinary calcium, phosphate and BUN in patients with vit D-resistant rickets. Monitor periodically serum calcium, phosphate, Mg and alkaline phosphatase and 24-hr urinary Ca and phosphate in patients with hypoparathyroid and those undergoing dialysis. Initially, determine serum Ca once or twice wkly while maintaining serum Ca levels at 9-10 mg/dL. Infants. Elderly with coronary disease, renal function impairment or calculi and arteriosclerosis. Pregnancy; lactation.
Phản ứng phụ
Weakness, headache; somnolence; nausea, vomiting, dry mouth, constipation; muscle pain, bone pain, metallic taste; polyuria, polydipsia; anorexia, irritability; wt loss, nocturia, mild acidosis, hypercalciuria; anaemia, reversible azotaemia, generalized vascular calcification, nephrocalcinosis; calcific conjunctivitis; pancreatitis; photophobia; rhinorhhoea; pruritus; hyperthermia; decreased libido; elevated BUN, albuminuria, hypercholesterolaemia, elevated AST and ALT; ectopic calcification; hyertension, cardiac arrhythmias, overt psychosis. Mental retardation.
Tương tác
Increases conc of magnesium-containing antacids leading to hypermagnaesemia in patients on chronic renal dialysis. Increases digitalis glycoside conc resulting in hypercalcaemia and may precipitate cardiac arrhythmia. Increases verapamil conc resulting in atrial fibrillation. Cholestyramine and prolonged use of mineral oil decrease ergocalciferol absorption in the intestines. Thiazide diuretics may cause hypercalcaemia in hypoparathyroid patients on vit D therapy.
Food Interaction
Concomitant vit D intake with fortified foods, dietary supplements requires a limited vit D diet.
Tác dụng
Description: Ergocalciferol as one of vit D metabolite shares the same action as its parent compound. It is involved in the control of intestinal absorption of dietary calcium, tubular reabsorption of calcium, and in conjunction with PTH (PTH), Ca transport from the skeleton. It stimulates skeletal growth by directly acting on osteoblasts and inhibits PTH synthesis and secretion at the parathyroid gland. In addition, ergocalciferol participates in Mg metabolism.
Onset: 10-24 hr.
Duration: ≥2 mth.
Pharmacokinetics:
Absorption: Slowly and partially absorbed from the small intestine in comparison with cholecalciferol.
Distribution: Hepatic; with small conc found in fat, muscle, skin and bones; bound to globulins and albumin.
Metabolism: Hydroxylation in the liver by the enzyme vit D 25-hydroxylase forming 25-hydroxyergocalciferol, then undergoes further metabolism via kidneys. Enters the breast milk.
Excretion: Via bile and faeces; small fraction via urine and limited amounts via breast milk.
Bảo quản
Store at 15-30°C.
Phân loại MIMS
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