Febuxostat


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Hyperuricaemia
Adult: For chronic cases in patients with gout or urate deposition (including a history, or presence of tophus and/or gouty arthritis): Initially, 40 mg once daily. Dose may be increased to 80 mg once daily if serum uric acid is >6 mg/dL after 2 weeks. Alternatively, 80 mg once daily. May increase dose to 120 mg once daily if serum uric acid is >6 mg/dL after 2-4 weeks. Gout flare prophylaxis for at least 6 months with an NSAID or colchicine is recommended at treatment initiation.

Oral
Cancer therapy-induced hyperuricaemia
Adult: Prophylaxis and treatment of cases in patients undergoing chemotherapy for haematologic malignancies at intermediate to high risk of tumour lysis syndrome (TLS): 120 mg once daily. Started 2 days before the beginning of cytotoxic therapy and continued for 7-9 days based on chemotherapy duration.
Renal Impairment
Hyperuricaemia:
CrCl (mL/min) Dosage
<30 Max: 40 mg once daily.
Hepatic Impairment
Hyperuricaemia:
Mild: Max: 80 mg daily.
Cách dùng
May be taken with or without food. May be taken w/o regard to antacid use.
Chống chỉ định
Concomitant use with azathioprine, mercaptopurine.
Thận trọng
Patient with history of hypersensitivity reaction to allopurinol; major CV disease (e.g. MI, stroke, unstable angina), ischaemic heart disease or CHF; thyroid disorders. Not to be started during an acute attack of gout; continue treatment if acute attacks occur in patients already receiving febuxostat, and treat the acute attack separately. Should only be used in patients who have an inadequate response to a maximally titrated allopurinol dose, who are intolerant to allopurinol, or when treatment with allopurinol is not advisable. Not recommended in organ transplant recipients, patients at increased risk of urate formation (e.g. Lesch-Nyhan syndrome, malignant disease and its treatment) or for the treatment of asymptomatic hyperuricaemia. Hepatic and severe renal impairment. Pregnancy and lactation.
Phản ứng phụ
Significant: MI, stroke; gout flares, xanthine deposition, LFT abnormalities (e.g. increased serum AST/ALT), increased TSH.
Cardiac disorders: Palpitation, left bundle branch block, sinus tachycardia.
Eye disorders: Rarely, blurred vision.
Gastrointestinal disorders: Diarrhoea, nausea, altered taste, abdominal pain.
General disorders and administration site conditions: Oedema.
Musculoskeletal and connective tissue disorders: Arthralgia.
Nervous system disorders: Headache, dizziness, paraesthesia.
Psychiatric disorders: Somnolence.
Skin and subcutaneous tissue disorders: Rash.
Vascular disorders: Flushing, hypertension, haemorrhage.
Potentially Fatal: CV death, hepatic failure. Rarely, hypersensitivity (e.g. acute anaphylactic shock) and serious skin reactions (e.g. Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms).
Thông tin tư vấn bệnh nhân
This drug may cause dizziness, somnolence, paraesthesia and blurred vision; if affected, do not drive or operate machinery.
MonitoringParameters
Monitor LFTs at baseline and periodically thereafter; serum uric acid levels 2 weeks after initiation of treatment; baseline renal function. Monitor cardiac function as clinically indicated in patients undergoing chemotherapy for haematologic malignancies at intermediate to high risk of TLS. Assess for gout flares, and signs or symptoms of CV events, liver injury, and hypersensitivity or severe skin reactions.
Tương tác
May increase the plasma concentrations of theophylline. May decrease the efficacy with potent UGT enzyme inducers.
Potentially Fatal: Increased plasma concentrations resulting in severe toxicity of mercaptopurine and azathioprine.
Tác dụng
Description: Febuxostat is a potent, non-purine, selective inhibitor of xanthine oxidase, the enzyme that catalyses the conversion of hypoxanthine to xanthine to uric acid. The inhibition of xanthine oxidase decreases the serum concentrations of uric acid.
Pharmacokinetics:
Absorption: Rapidly and well absorbed from the gastrointestinal tract. Time to peak plasma concentration: 1-1.5 hours.
Distribution: Plasma protein binding: Approx 99%, mainly to albumin.
Metabolism: Extensively metabolised via conjugation by the uridine diphosphate glucuronosyltransferase (UGT) enzyme system and via oxidation by the CYP450 isoenzyme system into active hydroxyl metabolites.
Excretion: Via urine (approx 49% as metabolites and 3% as unchanged drug); faeces (approx 45% as metabolites and 12% as unchanged drug). Elimination half-life: Approx 5-8 hours.
Đặc tính

Chemical Structure Image
Febuxostat

Source: National Center for Biotechnology Information. PubChem Database. Febuxostat, CID=134018, https://pubchem.ncbi.nlm.nih.gov/compound/Febuxostat (accessed on Jan. 20, 2020)

Bảo quản
Store between 15-30°C. Protect from light.
Phân loại ATC
M04AA03 - febuxostat ; Belongs to the class of preparations inhibiting uric acid production. Used in the treatment of gout.
References
Anon. Febuxostat. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 02/06/2020.

Anon. Febuxostat. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/06/2020.

Atenurix Film-Coated Tablets (Ajanta Pharma Philippines, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 17/08/2020.

Buckingham R (ed). Febuxostat. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/06/2020.

Feburic 80 mg Tablet (Astellas Pharma [Thailand] Co., Ltd). MIMS Thailand. http://www.mims.com/thailand. Accessed 17/08/2020.

Febuxostat 80 mg Film-Coated Tablets (Winthrop Pharmaceuticals UK Limited). MHRA. https://products.mhra.gov.uk/. Accessed 02/06/2020.

Febuxostat Accord 120 mg Film-Coated Tablets (Accord Healthcare Limited). MHRA. https://products.mhra.gov.uk/. Accessed 17/08/2020.

Febuxostat Mylan 80 mg Film-Coated Tablets (Mylan S.A.S.). European Medicines Agency [online]. Accessed 02/06/2020.

Joint Formulary Committee. Febuxostat. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/06/2020.

Uloric Tablet (Takeda Pharmaceuticals America, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 02/06/2020.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Febuxostat từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2021 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
  • Goclio
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in