Monotherapy or adjunct in refractory partial seizures with or without secondary generalisation
Adult: In severe cases unresponsive to other drugs: As monotherapy: Initially, 1.2 g daily in 3 or 4 divided doses, may increase gradually by 0.6 g every 2 wk up to 2.4 g daily. May further increase if needed. Max: 3.6 g daily. As adjunctive treatment: Initially, 1.2 g daily in 3 or 4 divided doses, may increase by 1.2 g at wkly intervals up to 3.6 g daily. Reduce the dose of concomitant anticonvulsants by 20-33% when initiating felbamate therapy.
Child: As adjunct in Lennox-Gastaut syndrome: 2-<14 yr Initially, 15 mg/kg daily in 3 or 4 divided doses, may increase gradually in increments of 15 mg/kg at wkly intervals. Max: 45 mg/kg daily. Reduce the dose of concomitant anticonvulsants by 20% when initiating felbamate therapy; ≥14 yr Same as adult dose.
Child: As adjunct in Lennox-Gastaut syndrome: 2-<14 yr Initially, 15 mg/kg daily in 3 or 4 divided doses, may increase gradually in increments of 15 mg/kg at wkly intervals. Max: 45 mg/kg daily. Reduce the dose of concomitant anticonvulsants by 20% when initiating felbamate therapy; ≥14 yr Same as adult dose.