Fexofenadine


Thông tin thuốc gốc
Chỉ định và Liều dùng
Oral
Seasonal allergic rhinitis
Adult: 120 mg once daily. Alternatively, 60 mg bid or 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: 2-11 years 30 mg bid; ≥12 years Same as adult dose. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).

Oral
Chronic idiopathic urticaria
Adult: 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Child: 6 months-<2 years 15 mg bid; 2-11 years 30 mg bid; ≥12 years 60 mg bid or 180 mg once daily. Dosing recommendations may vary among individual products and between countries (refer to specific product guidelines).
Cách dùng
Should be taken on an empty stomach. Do not take w/ fruit juice.
Thận trọng
Patient with current or history of CV disease. Renal and hepatic impairment. Children. Pregnancy and lactation.
Tác dụng không mong muốn
Cardiac disorders: Palpitations, tachycardia.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea, dyspepsia.
General disorders and administration site conditions: Fatigue.
Immune system disorders: Hypersensitivity reactions (e.g. angioedema, chest tightness, flushing).
Nervous system disorders: Headache, drowsiness, dizziness.
Psychiatric disorders: Insomnia, nervousness, sleep disorders or nightmares.
Skin and subcutaneous tissue disorders: Rash, urticaria, pruritus.
Chỉ số theo dõi
Monitor relief of symptoms.
Quá liều
Symptoms: Dizziness, drowsiness, fatigue and dry mouth. Management: Symptomatic and supportive treatment.
Tương tác
Increased plasma concentrations with erythromycin and ketoconazole. Reduced bioavailability and absorption with antacids containing Al and Mg.
Tương tác với thức ăn
Decreased bioavailability with high-fat meals, fruit juice (e.g. apple, grapefruit, orange).
Ảnh hưởng đến kết quả xét nghiệm
May suppress the wheal and flare reactions to skin test antigens.
Tác dụng
Description: Fexofenadine is a non-sedating antihistamine and an active metabolite of terfenadine. It competes with histamine for H1-receptor on effector cells in the blood vessels, gastrointestinal tract and respiratory tract.
Onset: 2 hours.
Duration: 24 hours.
Pharmacokinetics:
Absorption: Rapidly absorbed from the gastrointestinal tract. Bioavailability: Approx 33%; decreased with high-fat meals, fruit juice. Time to peak plasma concentration: Approx 2.6 hours (conventional tab); 2 hours (orally disintegrating tab); approx 1 hour (susp).
Distribution: Plasma protein binding: 60-70%, mainly to albumin and α1-acid glycoprotein.
Metabolism: Undergoes minimal metabolism in the liver (approx 5%) into methylester metabolite.
Excretion: Mainly via faeces (80%); urine (12%, as unchanged drug). Elimination half-life: 14.4 hours.
Đặc tính

Chemical Structure Image
Fexofenadine

Source: National Center for Biotechnology Information. PubChem Database. Fexofenadine, CID=3348, https://pubchem.ncbi.nlm.nih.gov/compound/Fexofenadine (accessed on Jan. 20, 2020)

Bảo quản
Store between 20-25°C.
Phân loại MIMS
Thuốc kháng histamin & kháng dị ứng
Phân loại ATC
R06AX26 - fexofenadine ; Belongs to the class of other antihistamines for systemic use.
Tài liệu tham khảo
Anon. Fexofenadine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 02/03/2022.

Buckingham R (ed). Fexofenadine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/02/2022.

Childrens Fexofenadine Hydrochloride Allergy Suspension (Taro Pharmaceuticals U.S.A., Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 10/02/2022.

Fexofenadine Cipla 120 mg Film-Coated Tablets (Cipla [EU] Limited). MHRA. https://products.mhra.gov.uk. Accessed 10/02/2022.

Fexofenadine HCL Tablet (Akron Pharma Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 10/02/2022.

Fexofenadine Hydrochloride 180 mg Film-Coated Tablets (Generics [UK] Limited t/a Mylan). MHRA. https://products.mhra.gov.uk. Accessed 10/02/2022.

Joint Formulary Committee. Fexofenadine Hydrochloride. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/02/2022.

Pharmacy Retailing (NZ) Limited Trading as Healthcare Logistics. Telfast 6-11 Years 30 mg Film Coated Tablets; Telfast 60 mg Film Coated Tablets; Telfast 120 mg Film Coated Tablets; Telfast 180 mg Film Coated Tablets; Telfast Oral Liquid, 6 mg/mL Suspension data sheet 20 December 2021. Medsafe. http://www.medsafe.govt.nz. Accessed 10/02/2022.

Telfast 180 mg Tablets (DKSH Malaysia Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 10/02/2022.

Telfast 30 mg Film-Coated Tablets (Sanofi). MHRA. https://products.mhra.gov.uk. Accessed 10/02/2022.

Telfast 30 mg/5 mL Oral Suspension (DKSH Malaysia Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 10/02/2022.

Thông báo miễn trừ trách nhiệm: Thông tin này được MIMS biên soạn một cách độc lập dựa trên thông tin của Fexofenadine từ nhiều nguồn tài liệu tham khảo và được cung cấp chỉ cho mục đích tham khảo. Việc sử dụng điều trị và thông tin kê toa có thể khác nhau giữa các quốc gia. Vui lòng tham khảo thông tin sản phẩm trong MIMS để biết thông tin kê toa cụ thể đã qua phê duyệt ở quốc gia đó. Mặc dù đã rất nỗ lực để đảm bảo nội dung được chính xác nhưng MIMS sẽ không chịu trách nhiệm hoặc nghĩa vụ pháp lý cho bất kỳ yêu cầu bồi thường hay thiệt hại nào phát sinh do việc sử dụng hoặc sử dụng sai các thông tin ở đây, về nội dung thông tin hoặc về sự thiếu sót thông tin, hoặc về thông tin khác. © 2022 MIMS. Bản quyền thuộc về MIMS. Phát triển bởi MIMS.com
XEM THÊM
LESS
  • AgimFast
  • Aleact
  • Alerday
  • Allerfen
  • Allerphast
  • Allerstat
  • Altiva
  • Amfendin
  • Axofen
  • Bixofen
  • Cadifast
  • Chemadin
  • Danapha-Telfadin
  • Dofexo
  • Entefast
  • Fanozo
  • Fegra 60/120/180
  • Fenafex
  • Fenidofex
  • Fexalar
  • Fexa-RB
  • Fexet
  • Fexidine
  • Fexihist
  • Fexo/Torfast
  • FexodineFast
  • Fexofast
  • Fexon
  • Fexophar
  • Fexotamin
  • Finarine
  • Fixdep
  • Genfix
  • Geofoxf
  • Glodas
  • Hasalfast/Fexofenaderm
  • Histaloc 120
  • Histofen
  • Imexofen
  • Inflex
  • Intas Allegix-120
  • Kofixir
  • Robfexo
  • Telfadin
  • Telfast
  • Telfor 120
  • Telfor 180
  • Telfor 60
  • Telgate
  • Tilfur
  • Tocimat
  • Ultigra
  • Xonadin
  • Xonatrix Forte
Register or sign in to continue
Asia's one-stop resource for medical news, clinical reference and education
Sign up for free
Already a member? Sign in