Adult: 50-300 mcg daily, usually given in combination w/ cortisone or hydrocortisone. Dosage depends on the severity of the disease and patient’s response.
Oral Salt-losing adrenogenital hyperplasia
Adult: 100-200 mcg daily.
Should be taken with food.
Chống chỉ định
Systemic infections not controlled by antibiotics.
Patient w/ HTN, heart failure, DM, GI diseases (e.g. diverticulitis, active or latent peptic ulcer, ulcerative colitis, fresh intestinal anastomoses, abscess or other pyogenic infection), myasthenia gravis, cataract and/or glaucoma, osteoporosis, thyroid disease, history of seizure disorder. Renal and hepatic impairment. Pregnancy and lactation.
Monitor BP, blood glucose, electrolytes, wt, salt intake.
May increase risk of arrhythmias or toxicity w/ digitalis glycosides. May decrease prothrombin time response to oral anticoagulants. May decrease the therapeutic effect of antidiabetic drugs and aspirin. May diminish response to vaccines. Enhanced hypokalaemic effect w/ amphotericin B or K-depleting diuretics (e.g. benzothiadiazines, furosemide, etacrynic acid). Increased metabolic clearance w/ barbiturates, phenytoin, rifampicin. Increased risk of oedema w/ anabolic steroids particularly C-17 alkylated androgens (e.g. oxymetholone). Estrogens may increase levels of corticosteroid-binding globulin, thereby increasing the bound (inactive) fraction. May antagonise effect of anticholinesterase agents. May enhance neutropenic effect of immunosuppressants. May enhance adverse effect of NSAIDs.
Ảnh hưởng đến kết quả xét nghiệm
May produce false-negative results in nitrobluetetrazolium test for bacterial infection. May suppress reaction to skin tests.
Description: Fludrocortisone is a corticosteroid w/ glucocorticoid and very potent mineralocorticoid activity. It acts on the renal distal tubules to promote the reabsorption of Na ions and increase the urinary excretion of K and hydrogen ions. Pharmacokinetics: Absorption: Rapidly and completely absorbed from the GI tract. Distribution: Widely distributed throughout the body. Enters breast milk. Plasma protein binding: 70-80%, mainly to globulin fractions. Metabolism: Hepatic. Excretion: Elimination half-life: ≥3.5 hr (plasma); 18-36 hr (biological).
Store between 15-30°C. Protect from excessive heat.
H02AA02 - fludrocortisone ; Belongs to the class of mineralocorticoids. Used in systemic corticosteroid preparations.
Tài liệu tham khảo
Anon. Fludrocortisone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 08/03/2017 .Buckingham R (ed). Fludrocortisone Acetate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2017 .Fludrocortisone Acetate Tablet (Teva Pharmaceuticals USA, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 08/03/2017 .Joint Formulary Committee. Fludrocortisone Acetate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/03/2017 .McEvoy GK, Snow EK, Miller J et al (eds). Fludrocortisone Acetate. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 08/03/2017 .