2 mg: The most significant adverse reaction is hypoglycemia.
Common (1/100 ≤ ADR < 1/10): Nervous system: Dizziness, fainting, headache.
Gastrointestinal: Nausea, vomiting, epigastric distension, abdominal pain, diarrhea.
Eye: Visual disturbance, transient, may occur especially on initiation of treatment, due to changes in blood glucose levels.
Uncommon (1/1,000 ≤ ADR < 1/100): Skin: Allergic or false allergic reactions, rash, urticaria, pruritus.
Rarely (1/10,000 ≤ ADR < 1/1,000): Hepatic: Hepatic enzymes increased, jaundice, hepatic failure.
Blood: Thrombocytopenia (mild or severe), hemolytic anemia, erythropenia, leukopenia, granulocytopenia.
Vascular system: Leukocytoclastic vasculitis.
4 mg: Hypoglycemia, dizziness, asthenia, headache, nausea.
Gastrointestinal reactions: Vomiting, gastrointestinal pain, and diarrhea. In rare cases, there may be an elevation of liver enzyme levels. In isolated instances, impairment of liver function (e.g. with cholestasis and jaundice), as well as hepatitis.
Dermatologic reactions: Porphyria cutanea tarda, photosensitivity reactions, and allergic vasculitis.
Hematologic reactions: Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia and pancytopenia.
Metabolic reactions: Hepatic porphyria reactions and disulfiram-like reactions, hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH).
Other reactions: Changes in accommodation and/or blurred vision.