Glimepiride STELLA 2 mg/Glimepiride STELLA 4 mg is orally taken. The drug usually is administered as a single daily dose given each morning with breakfast or with the first main meal.
Initial dosage in previously untreated patients: The usual initial adult dosage of glimepiride is 1-2 mg once daily. In debilitated, malnourished, or geriatric patients and in patients with hepatic or renal impairment and other patients at increased risk of hypoglycemia, the initial dosage of glimepiride should be 1 mg once daily.
Initial dosage in patients transferred from other antidiabetic agents: 2 mg: For the switch over to glimepiride, the strength and the half-life of the previous medicinal product has to be taken into account. In some cases, especially in antidiabetics with a long half-life (e.g. chlorpropamide), a wash out period of a few days is advisable in order to minimize the risk of hypoglycaemic reactions due to the additive effect. The initial dosage of glimepiride should be 1-2 mg once daily. The maximum dosage should not exceed 2 mg daily.
4 mg: The initial dosage of glimepiride in adults should be 1-2 mg once daily. The maximum dosage should not exceed 2 mg daily.
Maintenance dosage: The usual maintenance dosage of glimepiride from 1 - 4 mg once daily. In patients receiving 1 mg of glimepiride daily, the dosage may be increased to 2 mg daily if adequate glycemic control has not been achieved after 1 - 2 weeks. After reaching the 2 mg dosage, subsequent dosage should be adjusted according to the patient's tolerance and therapeutic response, increasing the dosage in increments of no more than 2 mg daily at 1- to 2-week intervals. The maximum recommended dosage of glimepiride is 8 mg daily.