Drug interactions: Coadministrations tend to produce hypoglycemia: Sulfonylurea and nonsteroidal anti-inflammatory drugs and other drugs that are highly protein bound, such as salicylates, sulfonamides, chloramphenicol, coumarin, probenecid, monoamine oxidase inhibitors, and beta adrenergic blocking agents.
Coadministrations tend to produce hyperglycemia and may lead to loss of control: Sulfonylurea and the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics and isoniazid.
A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported.
There is potential interaction of glimepiride with inhibitors (e.g. fluconazole) and inducers (e.g. rifampicin) of cytochrome P450 2C9.
Drug incompatibilities: In the absence of incompatibility studies, this medicinal product must not be mixed with other medicinal products.