The most significant adverse reaction is hypoglycemia.
Common (1/100 ≤ ADR < 1/10): Nervous system:
Dizziness, fainting, headache.
Nausea, vomiting, epigastric distension, abdominal pain, diarrhea.
Visual disturbance, transient, may occur especially on initiation of treatment, due to changes in blood glucose levels.
Uncommon (1/1,000 ≤ ADR < 1/100): Skin:
Allergic or false allergic reactions, rash, urticaria, pruritus.
Rarely (1/10,000 ≤ ADR < 1/1,000): Hepatic:
Hepatic enzymes increased, jaundice, hepatic failure.
Thrombocytopenia (mild or severe), hemolytic anemia, erythropenia, leukopenia, granulocytopenia.
Hypoglycemia, dizziness, asthenia, headache, nausea.
Vomiting, gastrointestinal pain, and diarrhea. In rare cases, there may be an elevation of liver enzyme levels. In isolated instances, impairment of liver function (e.g. with cholestasis and jaundice), as well as hepatitis.
Porphyria cutanea tarda, photosensitivity reactions, and allergic vasculitis.
Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia and pancytopenia.
Hepatic porphyria reactions and disulfiram-like reactions, hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH).
Changes in accommodation and/or blurred vision.