Hasanbest

Hasanbest

glibenclamide + metformin

Nhà sản xuất:

Hasan-Dermapharm
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Contents
Glibenclamide, metformin hydrochloride.
Description
Each tablet 500/5 contains: metformin hydrochloride 500 mg, glibenclamide 5 mg.
Each tablet 500/2.5 contains: metformin hydrochloride 500 mg, glibenclamide 2.5 mg.
Action
ATC Code: A10BD02.
Indications/Uses
Management of type II diabetes mellitus in combination with dietary management and exercise.
Dosage/Direction for Use
Use this medicine as directed by the doctor.
Initial dose: 1 - 2 tablets daily, dosage increases of 1 tablet every 1 - 2 weeks, if necessary, to maximum of 5 tablets daily, divided into 2 daily doses.
Elderly: Maximum dosage should not be used.
Renal impairment/renal diseases: Do not use.
ADMINISTRATION: Take 30 min before meals.
Contraindications
Hypersensitivity to any of the compositions. Type 1 diabetes mellitus, metabolic acidosis, diabetic pre-coma. Renal failure, dehydration, fever, severe infection. Hepatic failure, acute alcohol intoxication. Congestive heart failure, cardiovascular collapse, acute myocardial infarction. Iodinated X-ray contrast media. Combination with miconazole. Pregnant and breast feeding women.
Special Precautions
Discontinue drug in the presence of vomiting, abdominal pain with cramps, discomfort. Patients with malnutrition, cerebrovascular sclerosis and elderly. Allergy to sulfonamides and derivatives, lactic acidosis. Discontinue drug 2 - 3 days before, during and after surgery. Renal or hepatic impairment. Driving and using machines.
Adverse Reactions
Loss of appetite, nausea, vomiting, diarrhea, abdominal pain, full of epigastric, constipation, heartburn, rash, urticaria, decrease of vitamin B12 levels.
Uncommon: hypoglycaemia, myelodysplastic syndromes, aplastic anemia, hemolytic anemia, myelosuppression, thrombocytopenia, agranulocytosis. Lactic acidosis.
Drug Interactions
Diuretic, corticosteroids, phenothiazine, thyroid preparations, oestrogens, oral contraceptives, phenytoin, isoniazid, nicotinic acid, calcium blockers, like-sympathomimetic agents, furosemide, amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, triamterene, trimethoprim, vancomycin, sulfonamide, salicylate, phenylbutazone, NSAIDs, fluoroquinolones, coumarin derivatives, beta-blockers, ACE inhibitors, perhexiline, chloramphenicol, clofibrate, fenofibrate, sulfinpyrazone, probenecid, pentoxifylline, cyclophosphamide, azapropazone, tetracycline, fluconazole, miconazole, ciprofloxacin, enoxacin, MAO inhibitors and alcohol, thiazide, furosemide, ethacrynic acid, contraceptives containing estrogen/gestagen, phenothiazine derivatives, nicotinic acid (high dosage), sympathomimetic drugs, thyroid hormones and corticosteroids, tuberculosis medicine, salbutamol, or terbutaline.
MIMS Class
ATC Classification
A10BD02 - metformin and sulfonylureas ; Belongs to the class of combinations of oral blood glucose lowering drugs. Used in the treatment of diabetes.
Presentation/Packing
2.5 mg/500 mg FC tab 2 x 15's, 8 x 15's. 5 mg/500 mg FC tab 2 x 15's, 8 x 15's.
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